Involvement of GABAA Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal.
Hydroxycitronellal (HC) is a monoterpene present in essential oils of aromatic plants of different species, obtained from semisynthesis of citronellal, and is widely used as a fragrance in cosmetics. The objective of this work was to evaluate the possible anxiolytic-like activity of HC and its possi...
| Published in: | BioMed Research International pp. 1 - 18 |
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| Main Authors: | , , , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
6/17/2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=150967541&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 150967541 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 6/17/2021 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 150967541 150967541 150967541 10.1155/2021/9929805 150967541 ppf: 1 ppct: 17 formats: fmt: @attributes: type: P tig: atl: Involvement of GABAA Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal. aug: au: Andrade, Jéssica C. Monteiro, Álefe B. Andrade, Humberto H. N. Gonzaga, Thallita K. S. N. Silva, Pablo R. Alves, Danielle N. Castro, Ricardo D. Maia, Mayara S. Scotti, Marcus T. Sousa, Damião P. Almeida, Reinaldo N. affil: Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, Campus I, 58051-085, Via Ipê Amarelo/SN, João Pessoa, Paraíba, Brazil sug: subj: Receptors, Cell Surface GABA Antianxiety Agents Therapeutic Use Odors Essential Oils Administration and Dosage Plants, Medicinal Pharmacodynamics Plants, Medicinal Administration and Dosage Terpenes Administration and Dosage Animal Studies Molecular Structure In Vivo Studies Models, Biological Mice Descriptive Statistics Anxiety Drug Therapy Behavior, Animal Drug Effects Dose-Response Relationship, Drug ab: Hydroxycitronellal (HC) is a monoterpene present in essential oils of aromatic plants of different species, obtained from semisynthesis of citronellal, and is widely used as a fragrance in cosmetics. The objective of this work was to evaluate the possible anxiolytic-like activity of HC and its possible mechanism of action using in vivo and in silico methodologies. Swiss male mice (Mus musculus) were treated with HC (12.5, 25, and 50 mg/kg, i.p.) and subjected to the rota rod, elevated plus maze, and open field tests. No significant impairments were observed in the rota rod tests for the motor activity of the animals treated with HC at 12.5, 25, and 50 mg/kg, i.p., indicating no myo-relaxing or sedative effects. In the elevated plus maze, HC (in the three doses) induced significant increases in the percentage of entries (respectively, 34.8%, 33.8%, and 38.6%) and in the length of stay (respectively, 49.9%, 56.1%, and 57.0%) in the open arms of the EPM, as well as the number of crossings in the open field tests. The mechanism of action of the compound's anxiolytic-like activity can be attributed to the involvement of GABAA receptors, and this interaction was observed in in vivo and in silico studies. For HC, the results suggest anxiolytic-like effects, possibly via modulation of the GABAergic system. The use of natural products to treat anxiety can become an alternative to existing synthetic products. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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