ADAPTIVE SPARSE K-MEANS AND OPTIMIZATION ENABLED NEURAL NETWORK FROM GENE-EXPRESSION DATA FOR CANCER CLASSIFICATION.

Cancer is one of the malignant diseases existing globally and the people affected with cancer are rescued only when the disease is recognized at the earliest possible stage. Identify in advance of disease is essential as in the final stage; since the chance of living/existence is partial. The indica...

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Publicado en:Turkish Journal of Physiotherapy Rehabilitation Vol. 32; no. 2; pp. 2993 - 3005
Autores principales: BURRA, LAKSHMI RAMANI, RAVI, BHRAMARAMBA, RAMJI, BANOTHU, ALLADA, APPARNA, TUMULURU, PRAVEEN
Formato: equations & formulas tables/charts Journal Article
Publicado: Turkish Journal of Physiotherapy & Rehabilitation 2021
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2021
      vid: 32
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      pub: Turkish Journal of Physiotherapy & Rehabilitation
      place: Kizilay/ Ankara, <Blank>
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        atl: ADAPTIVE SPARSE K-MEANS AND OPTIMIZATION ENABLED NEURAL NETWORK FROM GENE-EXPRESSION DATA FOR CANCER CLASSIFICATION.
      aug:
        au:
          BURRA, LAKSHMI RAMANI
          RAVI, BHRAMARAMBA
          RAMJI, BANOTHU
          ALLADA, APPARNA
          TUMULURU, PRAVEEN
        affil: Assistant Professor, Dept. of CSE, PVP Siddhartha Institute of Technology, Vijayawada
      sug:
        subj:
          Neural Networks (Computer)
          Gene Expression
          Neoplasms Classification
          Health Beliefs
          Algorithms Utilization
          Microarray Analysis
          Databases
          Sequence Analysis
      ab: Cancer is one of the malignant diseases existing globally and the people affected with cancer are rescued only when the disease is recognized at the earliest possible stage. Identify in advance of disease is essential as in the final stage; since the chance of living/existence is partial. The indications of cancers are difficult and thus, all the indications should be considered accurately earlier to the diagnosis. Thus, an automatic prediction system is essential for classifying the tumor to malignant or benign. This work introduces a cancer classification approach using Chronological Grasshopper Optimization Algorithm (Chronological-GOA) for classification of cancer. For reducing the dimension of gene-expression data, log transformation is applied to the database. Then, the adaptive sparse K-means clustering selects the necessary data, which is provided to the Deep Belief Network (DBN). Here, the DBN is trained using Chronological-GOA. At last, the DBN classifies the selected gene sequences as normal and abnormal gene, and thereby identify the cancer. The performance of the cancer classification based on MSparse Kmeans + Chronological GOA-DBN is computed based on accuracy, detection rate, and False Alarm Rate (FAR). The developed method attains the accuracy of 0.9876, maximal detection rate of 0.9893, and the minimal FAR of 0.0596.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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