The Neural Circuitry Underlying the "Rhythm Effect" in Stuttering.
Purpose: Stuttering is characterized by intermittent speech disfluencies, which are dramatically reduced when speakers synchronize their speech with a steady beat. The goal of this study was to characterize the neural underpinnings of this phenomenon using functional magnetic resonance imaging. Meth...
| Publicado en: | Journal of Speech, Language & Hearing Research Vol. 64; pp. 2325 - 2347 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
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American Speech-Language-Hearing Association
2021 Supplement
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=151199876&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 151199876 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10924388 1SM jtl: Journal of Speech, Language & Hearing Research issn: 10924388 maglogo: N pubinfo: dt: 2021 Supplement vid: 64 pid: 42 pub: American Speech-Language-Hearing Association artinfo: ui: 151199876 10.1044/2021_JSLHR-20-00328 ppf: 2325 ppct: 22 formats: fmt: @attributes: type: P size: 2.1MB tig: atl: The Neural Circuitry Underlying the "Rhythm Effect" in Stuttering. aug: au: Frankford, Saul A. Murray, Elizabeth S. Heller Masapollo, Matthew Cai, Shanqing Tourville, Jason A. Nieto-Castañón, Alfonso Guenther, Frank H. affil: Department of Speech, Language & Hearing Sciences, Boston University, MA Department of Biomedical Engineering, Boston University, MA Department of Radiology, Massachusetts General Hospital, Boston The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge su: Task performance Speech Neural circuitry Language rhythm Stuttering Tempo (Phonetics) Sentences (Grammar) Cerebellum Prefrontal cortex Neurophysiology Magnetic resonance imaging Functional connectivity Regression analysis Functional assessment sug: subj: Task performance Speech Diagnostic Imaging Centers Neural circuitry Language rhythm Stuttering Tempo (Phonetics) Sentences (Grammar) Cerebellum Prefrontal cortex Neurophysiology Magnetic resonance imaging Functional connectivity Regression analysis Functional assessment ab: Purpose: Stuttering is characterized by intermittent speech disfluencies, which are dramatically reduced when speakers synchronize their speech with a steady beat. The goal of this study was to characterize the neural underpinnings of this phenomenon using functional magnetic resonance imaging. Method: Data were collected from 16 adults who stutter and 17 adults who do not stutter while they read sentences aloud either in a normal, self-paced fashion or paced by the beat of a series of isochronous tones ("rhythmic"). Task activation and task-based functional connectivity analyses were carried out to compare neural responses between speaking conditions and groups after controlling for speaking rate. Results: Adults who stutter produced fewer disfluent trials in the rhythmic condition than in the normal condition. Adults who stutter did not have any significant changes in activation between the rhythmic condition and the normal condition, but when groups were collapsed, participants had greater activation in the rhythmic condition in regions associated with speech sequencing, sensory feedback control, and timing perception. Adults who stutter also demonstrated increased functional connectivity among cerebellar regions during rhythmic speech as compared to normal speech and decreased connectivity between the left inferior cerebellum and the left prefrontal cortex. Conclusions: Modulation of connectivity in the cerebellum and prefrontal cortex during rhythmic speech suggests that this fluency-inducing technique activates a compensatory timing system in the cerebellum and potentially modulates top-down motor control and attentional systems. These findings corroborate previous work associating the cerebellum with fluency in adults who stutter and indicate that the cerebellum may be targeted to enhance future therapeutic interventions. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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