Changes in the brain directly following alcohol consumption—a study of healthy male individuals, with the use of proton magnetic resonance spectroscopy (1HMRS) and diffusion (DWI).
Aims To use proton magnetic resonance spectroscopy (1HMRS) and diffusion weighted imaging (DWI) to identify ethanol in the brain directly after consumption, and examine changes in brain metabolite levels and brain microstructure relative to the duration of time following exposure to alcohol. Methods...
| Publicado en: | Alcohol & Alcoholism Vol. 56; no. 4; pp. 415 - 425 |
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| Autores principales: | , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jul2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151237192&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151237192 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jul2021 vid: 56 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 151237192 151237192 151237192 10.1093/alcalc/agaa119 151237192 ppf: 415 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Changes in the brain directly following alcohol consumption—a study of healthy male individuals, with the use of proton magnetic resonance spectroscopy (1HMRS) and diffusion (DWI). aug: au: Urbanik, Andrzej Kozub, Justyna Karcz, Paulina Ostrogórska, Monika affil: Department of Radiology , Collegium Medicum, Jagiellonian University , Krakow, Poland sug: subj: Brain Metabolism Ethanol Metabolism Metabolites Evaluation Brain Anatomy and Histology Alcohol Drinking Men's Health Proton Magnetic Resonance Spectroscopy Magnetic Resonance Imaging Methods Human Male Adolescence Young Adult Adult Frontal Lobe Occipital Lobe Basal Ganglia Cerebellum Pretest-Posttest Design Health Status Descriptive Statistics Time Factors Lipids Metabolism Lactates Metabolism GABA Metabolism Glucose Metabolism Choline Metabolism Creatine Metabolism Aspartic Acid Metabolism Inositol Metabolism Glutamine Metabolism Glutamic Acid Metabolism Adolescent: 13-18 years Adult: 19-44 years Male ab: Aims To use proton magnetic resonance spectroscopy (1HMRS) and diffusion weighted imaging (DWI) to identify ethanol in the brain directly after consumption, and examine changes in brain metabolite levels and brain microstructure relative to the duration of time following exposure to alcohol. Methods The study involved 44 male volunteers (18–55 years). All brain changes were assessed in the frontal lobes, occipital lobes, basal ganglia and cerebellum, however the detailed analyses focused on the frontal lobes. All participants were examined four times, i.e. before and 0.5-hour, 1 hour and 2 hours after consumption of 150 mL pure vodka (60 g of ethanol). Results The highest ethanol levels were identified between 0.5 and 1 hour following alcohol intake. There were significant increases in the concentrations of lipids and lactates approximately one hour after alcohol consumption, and the concentration levels were found to normalise during the following two hours. Some statistically insignificant trends of changes were found for tCr, tCho, mI, GABA, Glc, Glx and tNAA. For the DWI and ADC (Apparent Diffusion Coefficient of water) values, the findings showed statistically insignificant decrease and increase, followed by a tendency towards normalisation. Similar associations in changes of metabolite concentrations and DWI and ADC values were found in the other locations investigated in the study. Conclusion A single dose of alcohol as used in this experiment produces increases in lipids and lactates in brain tissues that appear reversible. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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