Serum Interleukin-24 Levels in Gastric and Breast Cancers and Non-cancerous Inflammations.
Background: Human interleukin-24 (IL-24) is a cytokine belonging to the interleukin-10 (IL-10) family of cytokines, also known as melanoma differentiationassociated gene 7, due to its discovery as a tumor-suppressing protein. A tumor-suppressing protein, IL-24 is produced by a variety of cells, incl...
| Published in: | Middle East Journal of Cancer Vol. 12; no. 2; pp. 183 - 190 |
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| Main Authors: | , , |
| Format: | research tables/charts Journal Article |
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Middle East Journal of Cancer
Apr2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151242015&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151242015 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20086709 B7LE jtl: Middle East Journal of Cancer issn: 20086709 maglogo: N pubinfo: dt: Apr2021 vid: 12 iid: 2 pid: 67247 pub: Middle East Journal of Cancer artinfo: ui: 151242015 151242015 151242015 10.30476/mejc.2020.82945.1122 151242015 ppf: 183 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Serum Interleukin-24 Levels in Gastric and Breast Cancers and Non-cancerous Inflammations. aug: au: Khoshroo, Mohammad Yazdanpanah, Mohammad Javad Yasrebi, Samira affil: Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran sug: subj: Interleukins Blood Stomach Neoplasms Blood Breast Neoplasms Blood Inflammation Blood Tumor Markers, Biological Blood Human Case Control Studies Enzyme-Linked Immunosorbent Assay Data Analysis Software Descriptive Statistics Female Male Adult Middle Age Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: Human interleukin-24 (IL-24) is a cytokine belonging to the interleukin-10 (IL-10) family of cytokines, also known as melanoma differentiationassociated gene 7, due to its discovery as a tumor-suppressing protein. A tumor-suppressing protein, IL-24 is produced by a variety of cells, including cancerous and non-cancerous healthy cells. The aim of the present study was to evaluate serum IL-24 concentrations in different cancers and compare them with non-cancerous inflammations. Method: In this case-control study, we divided a total of 200 subjects into five groups of 40 control subjects without cancer and without Helicobacter Pylori (H. Pylori) infection, patients with gastric cancer and H. Pylori infection, patients with H. Pylori infection without cancer, and patients with breast cancer and without H. Pylori infection. We measured the serum IL-24 level using specific enzyme-linked immunosorbent assay (ELISA) kit; we analysed the data with SPSS software. Results: The level of IL-24 was significantly higher in breast cancer group (160.65±55pg/mL) (mean± SD) followed by gastric cancer with (76.2±16.27 pg/mL) (mean±SD) and without (72.5±17.84 pg/mL) (mean± SD) H. Pylori infection groups. The level of IL-24 in H. Pylori infected patients and controls were (32.78±12.96 pg/mL) (mean±SD) and (27.4±8.5 pg/mL (mean±SD)), respectively. Conclusion: The mechanisms by which IL-24 is produced may be different between immune and cancer cells and serum IL-24 is more likely generated by immune cells than tumor cells. In breast cancer patients, estrogen or other sex hormones may provoke IL-24 production. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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