Phycocyanin C a Natural Product with Impressive Therapeutic Efficacy for Inhibition of Breast Tumors' Growth and Metastasis in Vivo.
Background: Several studies have reported the anticancer effect of phycocyanin C, a natural extract isolated from the algae Arthrospira platensis. However, its therapeutic effects on the growth of breast cancer and its metastasis have not been determined yet. Method: In this case-control study, we e...
| Published in: | Middle East Journal of Cancer Vol. 12; no. 2; pp. 261 - 269 |
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| Main Authors: | , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Middle East Journal of Cancer
Apr2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151242024&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151242024 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20086709 B7LE jtl: Middle East Journal of Cancer issn: 20086709 maglogo: N pubinfo: dt: Apr2021 vid: 12 iid: 2 pid: 67247 pub: Middle East Journal of Cancer artinfo: ui: 151242024 151242024 151242024 10.30476/mejc.2020.83064.1130 151242024 ppf: 261 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Phycocyanin C a Natural Product with Impressive Therapeutic Efficacy for Inhibition of Breast Tumors' Growth and Metastasis in Vivo. aug: au: Kefayat, Amirhosein Yuosefzadeh, Mohadeseh Goli, Parvin Babayi, Alireza Rezaei, Abbas Esmaeil, Nafiseh affil: Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran sug: subj: Pigments Therapeutic Use Plant Extracts Therapeutic Use Neoplasm Metastasis Drug Therapy Breast Neoplasms Drug Therapy Antineoplastic Agents Therapeutic Use Animal Studies In Vivo Studies Case Control Studies Models, Biological Plant Extracts Descriptive Statistics Injections ab: Background: Several studies have reported the anticancer effect of phycocyanin C, a natural extract isolated from the algae Arthrospira platensis. However, its therapeutic effects on the growth of breast cancer and its metastasis have not been determined yet. Method: In this case-control study, we employed phycocyanin C for the treatment of 4T1 breast tumor as an applicable experimental animal model for human mammary cancer and metastasis. BALB/c mice were injected subcutaneously (s.c) into the 4th abdominal mammary fat pad with 1.106 4T1 cells. We randomly divided the mice into two groups; one group of mice were injected with PBS as the control, and the other group was intraperitoneally injected with phycocyanin C (80 mg/kg daily for 20 days). Tumor growth and metastasis were assessed in both groups. Results: Phycocyanin C significantly inhibited 4T1 breast tumors growth (P<0.05). The mean tumors volumes at the control group were 2.73 times higher than those of the treatment group. In addition, phycocyanin C treatment could significantly inhibit the formation of metastasis colonies at vital organs like spleen, liver, and lung. Moreover, the survival rate of the tumor-bearing mice increased after about 22 days by phycocyanin C treatment in comparison with the control. Conclusion: This is the first report demonstrating the anticancer effects of phycocyanin C on 4T1 breast tumor in vivo. Overall, our findings provided convincing evidence for the application of phycocyanin C as an anticancer therapeutic agent. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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