L-type calcium channel blocker use and proteinuria among children with chronic kidney diseases.
Background: Hypertension is common among children with chronic kidney disease (CKD), and dihydropyridine calcium channel blockers (dhCCBs) are frequently used as treatment. The impact of dhCCBs on proteinuria in children with CKD is unclear. Methods: Data from 722 participants in the Chronic Kidney...
| Publicado en: | Pediatric Nephrology Vol. 36; no. 8; pp. 2411 - 2420 |
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| Autores principales: | , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151271301&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151271301 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Aug2021 vid: 36 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 151271301 148716075 151271301 151271301 10.1007/s00467-021-04967-3 151271301 ppf: 2411 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: L-type calcium channel blocker use and proteinuria among children with chronic kidney diseases. aug: au: Richardson, Kelsey L. Weaver, Donald J. Ng, Derek K. Carroll, Megan K. Furth, Susan L. Warady, Bradley A. Flynn, Joseph T. affil: Division of Pediatric Nephrology, Oregon Health & Sciences University, Portland, OR, USA sug: subj: Calcium Channel Blockers Therapeutic Use Proteinuria Risk Factors Kidney Failure, Chronic Hypertension Drug Therapy Child Prospective Studies Creatinine Blood Angiotensin-Converting Enzyme Inhibitors Angiotensin II Type I Receptor Blockers Systolic Pressure Diastolic Pressure Human Descriptive Statistics Child: 6-12 years ab: Background: Hypertension is common among children with chronic kidney disease (CKD), and dihydropyridine calcium channel blockers (dhCCBs) are frequently used as treatment. The impact of dhCCBs on proteinuria in children with CKD is unclear. Methods: Data from 722 participants in the Chronic Kidney Disease in Children (CKiD) longitudinal cohort with a median age of 12 years were used to assess the association between dhCCBs and log transformed urine protein/creatinine levels as well as blood pressure control measured at annual visits. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) use was evaluated as an effect measure modifier. Results: Individuals using dhCCBs had 18.8% higher urine protein/creatinine levels compared to those with no history of dhCCB or ACEi and ARB use. Among individuals using ACEi and ARB therapy concomitantly, dhCCB use was not associated with an increase in proteinuria. Those using dhCCBs had higher systolic and diastolic blood pressures. Conclusions: Use of dhCCBs in children with CKD and hypertension is associated with higher levels of proteinuria and was not found to be associated with improved blood pressure control. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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