Association between potentially inappropriate medication and adverse drug reactions in hospitalized elderly patients.
What is known and objective: The Beers, European Union (EU) and Screening Tool of Older Persons' potentially inappropriate Prescription (STOPP) criteria were developed to improve the safe use of medicines in the elderly. However, the predictive validity of existing criteria to detect adverse drug re...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 46; no. 4; pp. 1139 - 1148 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151285537&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151285537 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Aug2021 vid: 46 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 151285537 150015320 151285537 151285537 10.1111/jcpt.13413 151285537 ppf: 1139 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between potentially inappropriate medication and adverse drug reactions in hospitalized elderly patients. aug: au: Wang, Feifei Xu, Guishui Rong, Chengting Wu, Xinan affil: Pharmacy Department of Hefei BOE Hospital, Hefei, P. R. China sug: subj: Adverse Drug Event Hospitalization of Older Persons Inappropriate Prescribing Human Retrospective Design Cross Sectional Studies Tertiary Health Care China Multiple Logistic Regression Aged Aged, 80 and Over Univariate Statistics Odds Ratio Confidence Intervals Descriptive Statistics Aged: 65+ years Aged, 80 & over ab: What is known and objective: The Beers, European Union (EU) and Screening Tool of Older Persons' potentially inappropriate Prescription (STOPP) criteria were developed to improve the safe use of medicines in the elderly. However, the predictive validity of existing criteria to detect adverse drug reactions (ADRs) remains unexplored. The objective of the current study was to determine whether the 2019 Beers, 2015 STOPP or 2015 EU potentially inappropriate medicine (PIM) criteria were associated with ADRs. Methods: A retrospective, cross‐sectional investigation was conducted among older persons (≥60 years of age) admitted to a tertiary hospital in China between April 2019 and December 2019. PIMs were identified as per the Beers, EU and STOPP criteria definitions. ADRs were retrospectively evaluated by two clinical pharmacists using the Naranjo algorithm. Multivariate logistic regression was used to evaluate the factors associated with ADRs in the hospitalized patients. Results and discussion: The study participants included 560 hospitalized patients (mean age 72.05 ± 8.15). The prevalence of patients receiving at least one PIM was 52.1%, 37.0% and 42.9% according to the Beers, EU and STOPP criteria, respectively. Univariate analysis showed that ADRs were associated with PIMs listed in the Beers criteria (OR: 2.093, 95% CI: 1.028–4.263, 0.042), but not with the STOPP‐listed (OR: 0.536, 95% CI: 0.255–1.123, 0.098) and EU‐listed PIMs (OR: 0.258, 95% CI: 0.118–0.563, 0.001). What is new and conclusion: In contrast to the STOPP and EU criteria on PIMs, the Beers criteria were significantly associated with avoidable ADRs in hospitalized older persons. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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