| Sumario: | This article is part of the Topical Collection on Technology Introduction Thanks to companies' research and development processes, frequently involving fruitful partnerships with academic centres, and what could be acknowledged as welcome competition between PET vendors, new PET hardware and software technologies are regularly innovated and released as clinic-ready products. Advanced PET detectors Pushing the limit of detectability More recently, silicon photomultiplier (SiPM) technology has become available from the major PET vendors. Another important consideration is that PET technology is in constant development and rapidly evolving, the latest to date being SiPM PETs system and total-body PET. There were lesions only identified using the SiPM PET/CT showing that SiPM PET/CT has superior performance compared to a conventional PET/CT scanner [[41]]. Total-body PET Anybody involved in designing or analysing PET studies recognizes that limited detection sensitivity, and its consequence of image noise, is by far the biggest technical limitation in PET imaging, whether that be in clinical PET or in research studies.
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