Longitudinal associations of total and trunk fat in childhood and adolescence and risk of hepatic steatosis at 24 years.
Summary: Background: The importance of body fat distribution in the development of nonalcoholic fatty liver disease (NAFLD) is unclear. Objective: To examine whether total and truncal fat deposition patterns in childhood/adolescence are associated with NAFLD risk at 24 years. Methods: Data were from...
| Published in: | Pediatric Obesity Vol. 16; no. 8; pp. 1 - 11 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Aug2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151353345&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151353345 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20476302 ETV7 jtl: Pediatric Obesity issn: 20476302 maglogo: Y pubinfo: dt: Aug2021 vid: 16 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 151353345 148583801 151353345 151353345 10.1111/ijpo.12773 151353345 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Longitudinal associations of total and trunk fat in childhood and adolescence and risk of hepatic steatosis at 24 years. aug: au: Cohen, Catherine C. Sekkarie, Ahlia Figueroa, Janet Gillespie, Scott E. Vos, Miriam B. Welsh, Jean A. affil: Department of Pediatrics, Emory University School of Medicine, Atlanta Georgia, USA sug: subj: Torso Adipose Tissue Distribution Evaluation Adipose Tissue Distribution Evaluation Nonalcoholic Fatty Liver Disease Risk Factors Risk Assessment Human Prospective Studies Child Adolescence Adult Nonalcoholic Fatty Liver Disease In Adulthood Severity of Illness In Adulthood Absorptiometry, Photon Models, Statistical Descriptive Statistics Male Female Abdominal Fat Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Summary: Background: The importance of body fat distribution in the development of nonalcoholic fatty liver disease (NAFLD) is unclear. Objective: To examine whether total and truncal fat deposition patterns in childhood/adolescence are associated with NAFLD risk at 24 years. Methods: Data were from 1657 participants in the Avon Longitudinal Study of Parents and Children. Transient elastography was used to assess hepatic steatosis (low/moderate/severe) at 24 years and dual‐energy X‐ray absorptiometry was used to assess total body fat percent (TBF%) and trunk fat percent (TrF%) at 9, 13, 15, 17, and/or 24 years. Linear mixed models were constructed with quadratic age to examine trajectories of TBF% and TrF% by steatosis at 24 years, adjusting for confounders. Results: In both sexes, TBF% trajectories from 9 to 24 years followed a similar pattern based on steatosis group (P =.83 for boys and P =.14 for girls for age2*steatosis fixed effect). However, at all ages TBF% was higher for moderate/severe vs low steatosis at 24 years (P <.05). In contrast, TrF% trajectories diverged based on steatosis group (P =.001 for boys and P =.0002 for girls for age2*steatosis fixed effect), such that, in both sexes, participants with moderate/severe steatosis at 24 yrs exhibited less decline in TrF% from adolescence to adulthood compared to participants with low steatosis at 24 yrs. Similar to TBF%, TrF% was higher at nearly all ages for moderate/severe vs low steatosis. Results were similar after adjusting for BMI category at each age, except in boys some differences for TrF% were attenuated. Conclusions: These findings suggest that sex‐specific body fat distribution patterns in childhood/adolescence may help to identify those at risk of developing NAFLD in adulthood. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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