Effect of the intake of dietary protein on insulin resistance in subjects with obesity: a randomized controlled clinical trial.
Purpose: We compared the effect of diets with different amounts and sources of dietary protein on insulin sensitivity (IS) in subjects with obesity and insulin resistance (IR). Methods: Eighty subjects with obesity (BMI ≥ 30 kg/m2) and IR (Matsuda index < 4.3 and HOMA-IR ≥ 2.5) over 18 years old wer...
| Publicado en: | European Journal of Nutrition Vol. 60; no. 5; pp. 2435 - 2448 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Aug2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151386814&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151386814 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Aug2021 vid: 60 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 151386814 146880034 151386814 151386814 10.1007/s00394-020-02428-5 151386814 ppf: 2435 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Effect of the intake of dietary protein on insulin resistance in subjects with obesity: a randomized controlled clinical trial. aug: au: González-Salazar, Luis E. Pichardo-Ontiveros, Edgar Palacios-González, Berenice Vigil-Martínez, Ana Granados-Portillo, Omar Guizar-Heredia, Rocío Flores-López, Adriana Medina-Vera, Isabel Heredia-G-Cantón, Pamela K. Hernández-Gómez, Karla G. Castelán-Licona, Georgina Arteaga-Sánchez, Liliana Serralde-Zúñiga, Aurora E. Ávila-Nava, Azalia Noriega-López, Lilia G. Reyes-García, Juan G. Zerrweck, Carlos Torres, Nimbe Tovar, Armando R. Guevara-Cruz, Martha affil: Department of Nutrition Physiology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico sug: subj: Food Intake Dietary Proteins Insulin Resistance Obesity Diagnosis Diet Methods Insulin Sensitivity Human Randomized Controlled Trials Body Composition Anthropometry Descriptive Statistics Data Analysis Software Confidence Intervals Analysis of Variance Kruskal-Wallis Test T-Tests Male Female Young Adult Adult Middle Age Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: We compared the effect of diets with different amounts and sources of dietary protein on insulin sensitivity (IS) in subjects with obesity and insulin resistance (IR). Methods: Eighty subjects with obesity (BMI ≥ 30 kg/m2) and IR (Matsuda index < 4.3 and HOMA-IR ≥ 2.5) over 18 years old were randomized to four groups for a one-month period: a normal protein diet (< 20%) with a predominance of animal protein (Animal NP) or vegetable protein (Vegetable NP) and a high-protein diet (25–30%) with a predominance of animal protein (Animal HP) or vegetable protein (Vegetable HP). Baseline and final measurements of body weight, body composition, biochemical parameters, blood pressure (BP), resting energy expenditure and plasma amino acid profiles were performed. Results: Body weight, BMI and waist circumference decreased in all groups. Interestingly, the IS improved more in the Animal HP (Matsuda index; 1.39 vs 2.58, P = 0.003) and in the Vegetable HP groups (Matsuda index; 1.44 vs 3.14, P < 0.0001) after one month. The fat mass, triglyceride levels, C-reactive protein levels and the leptin/adiponectin index decreased; while, the skeletal muscle mass increased in the Animal and Vegetable HP groups. The BP decreased in all groups except the Animal NP group. Conclusion: Our study demonstrates that a high-protein hypocaloric diets improves IS by 60–90% after one month in subjects with obesity and IR, regardless of weight loss and the source of protein, either animal or vegetable. Trial registration: The trial is registered at clinicaltrials.gov (NCT03627104), August 13, 2018. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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