Assessment of agreement between manual and automated processing of liver MR elastography for shear stiffness estimation in children and young adults with autoimmune liver disease.
Purpose: To compare automated versus standard of care manual processing of 2D gradient recalled echo (GRE) liver MR Elastography (MRE) in children and young adults. Materials and methods: 2D GRE liver MRE data from research liver MRI examinations performed as part of an autoimmune liver disease regi...
| Publicado en: | Abdominal Radiology Vol. 46; no. 8; pp. 3927 - 3935 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151456950&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151456950 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Aug2021 vid: 46 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 151456950 149609672 10.1007/s00261-021-03073-0 151456950 ppf: 3927 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Assessment of agreement between manual and automated processing of liver MR elastography for shear stiffness estimation in children and young adults with autoimmune liver disease. aug: au: Gandhi, Deep B. Pednekar, Amol Braimah, Adebayo B. Dudley, Jonathan Tkach, Jean A. Trout, Andrew T. Miethke, Alexander G. Franck, Marnix D. Heilman, Jeremiah A. Dzyubak, Bogdan Lake, David S. Dillman, Jonathan R. affil: Department of Radiology, Imaging Research Center (IRC), Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA sug: ab: Purpose: To compare automated versus standard of care manual processing of 2D gradient recalled echo (GRE) liver MR Elastography (MRE) in children and young adults. Materials and methods: 2D GRE liver MRE data from research liver MRI examinations performed as part of an autoimmune liver disease registry between March 2017 and March 2020 were analyzed retrospectively. All liver MRE data were acquired at 1.5 T with 60 Hz mechanical vibration frequency. For manual processing, two independent readers (R1, R2) traced regions of interest on scanner generated shear stiffness maps. Automated processing was performed using MREplus+ (Resoundant Inc.) using 90% (A90) and 95% (A95) confidence masks. Agreement was evaluated using intra-class correlation coefficients (ICC) and Bland–Altman analyses. Classification performance was evaluated using receiver operating characteristic curve (ROC) analyses. Results: In 65 patients with mean age of 15.5 ± 3.8 years (range 8–23 years; 35 males) median liver shear stiffness was 2.99 kPa (mean 3.55 ± 1.69 kPa). Inter-reader agreement for manual processing was very strong (ICC = 0.99, mean bias = 0.01 kPa [95% limits of agreement (LoA): − 0.41 to 0.44 kPa]). Correlation between manual and A95 automated processing was very strong (R1: ICC = 0.988, mean bias = 0.13 kPa [95% LoA: − 0.40 to 0.68 kPa]; R2: ICC = 0.987, mean bias = 0.13 kPa [95% LoA: − 0.44 to 0.69 kPa]). Automated measurements were perfectly replicable (ICC = 1.0; mean bias = 0 kPa). Conclusion: Liver shear stiffness values obtained using automated processing showed excellent agreement with manual processing. Automated processing of liver MRE was perfectly replicable. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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