A whole-slide image grading benchmark and tissue classification for cervical cancer precursor lesions with inter-observer variability.

The cervical cancer developing from the precancerous lesions caused by the human papillomavirus (HPV) has been one of the preventable cancers with the help of periodic screening. Cervical intraepithelial neoplasia (CIN) and squamous intraepithelial lesion (SIL) are two types of grading conventions w...

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Publicado en:Medical & Biological Engineering & Computing Vol. 59; no. 7/8; pp. 1545 - 1562
Autores principales: Albayrak, Abdulkadir, Akhan, Asli Unlu, Calik, Nurullah, Capar, Abdulkerim, Bilgin, Gokhan, Toreyin, Behcet Ugur, Muezzinoglu, Bahar, Turkmen, Ilknur, Durak-Ata, Lutfiye
Formato: Journal Article
Publicado: Springer Nature Aug2021
Acceso en línea:Ver este registro en EBSCOhost
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        atl: A whole-slide image grading benchmark and tissue classification for cervical cancer precursor lesions with inter-observer variability.
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          Albayrak, Abdulkadir
          Akhan, Asli Unlu
          Calik, Nurullah
          Capar, Abdulkerim
          Bilgin, Gokhan
          Toreyin, Behcet Ugur
          Muezzinoglu, Bahar
          Turkmen, Ilknur
          Durak-Ata, Lutfiye
        affil: Department of Computer Engineering, Dicle University, 21280, Diyarbakır, Turkey
      sug:
        subj:
          Cervical Intraepithelial Neoplasia
          Cervix Neoplasms
          Observer Bias
          Benchmarking
          Female
          Female
      ab: The cervical cancer developing from the precancerous lesions caused by the human papillomavirus (HPV) has been one of the preventable cancers with the help of periodic screening. Cervical intraepithelial neoplasia (CIN) and squamous intraepithelial lesion (SIL) are two types of grading conventions widely accepted by pathologists. On the other hand, inter-observer variability is an important issue for final diagnosis. In this paper, a whole-slide image grading benchmark for cervical cancer precursor lesions is created and the "Uterine Cervical Cancer Database" introduced in this article is the first publicly available cervical tissue microscopy image dataset. In addition, a morphological feature representing the angle between the basal membrane (BM) and the major axis of each nucleus in the tissue is proposed. The presence of papillae of the cervical epithelium and overlapping cell problems are also discussed. Besides that, the inter-observer variability is also evaluated by thorough comparisons among decisions of pathologists, as well as the final diagnosis.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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