Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects.

Background: The anesthetic ketamine after intravenous dosing is nearly completely metabolized to R- and S-stereoisomers of the active norketamine (analgesic, psychoactive) and 2,6-hydroxynorketamine (potential analgesic, antidepressant) as well as the inactive dehydronorketamine. Oral administration...

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Publicado en:	Anesthesiology Vol. 135; no. 2; pp. 326 - 340
Autores principales:	Hasan, Mahmoud, Modess, Christiane, Roustom, Tarek, Dokter, Anne, Grube, Markus, Link, Andreas, Rey, Hélène, Adler, Stefanie, Meissner, Konrad, Siegmund, Werner
Formato:	research tables/charts Journal Article
Publicado:	Lippincott Williams & Wilkins Aug2021
Acceso en línea:	Ver este registro en EBSCOhost