The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects.
Purpose: The present study was performed to investigate the effect of oral dronabinol, a synthetic tetrahydrocannabinol derivate, on retinal hemodynamics in healthy subjects in a randomized, double-masked, placebo-controlled, 2-way crossover design. Methods: Twenty-four subjects received 5 mg dronab...
| Publicado en: | Journal of Ocular Pharmacology & Therapeutics Vol. 37; no. 6; pp. 360 - 367 |
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| Autores principales: | , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Jul/Aug2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151642676&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151642676 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10807683 2U7 jtl: Journal of Ocular Pharmacology & Therapeutics issn: 10807683 maglogo: N pubinfo: dt: Jul/Aug2021 vid: 37 iid: 6 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 151642676 151642676 NLM33999707 151642676 10.1089/jop.2020.0131 NLM33999707 151642676 ppf: 360 ppct: 7 formats: tig: atl: The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects. aug: au: Hommer, Nikolaus Schmidl, Doreen Kallab, Martin Bauer, Martin Werkmeister, René M. Schmetterer, Leopold Abensperg-Traun, Marihan Garhöfer, Gerhard affil: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. sug: subj: Oxygen Metabolism Cannabis Administration and Dosage Retina Physiology Blood Circulation Male Administration, Oral Blood Flow Velocity Female Retina Drug Effects Neurotransmitter Agents Administration and Dosage Adult Research Subjects Double-Blind Studies Crossover Design Human Dose-Response Relationship, Drug Comparative Studies Multicenter Studies Randomized Controlled Trials Evaluation Research Validation Studies Adult: 19-44 years Male Female ab: Purpose: The present study was performed to investigate the effect of oral dronabinol, a synthetic tetrahydrocannabinol derivate, on retinal hemodynamics in healthy subjects in a randomized, double-masked, placebo-controlled, 2-way crossover design. Methods: Twenty-four subjects received 5 mg dronabinol on 1 study day and placebo on the other study day. Total retinal blood flow (TRBF) was measured using a custom-built Doppler Optical Coherence Tomography system. Oxygen saturation of major retinal vessels was measured with a commercially available Dynamic Vessel Analyzer. Based on these parameters, retinal oxygen extraction was calculated. Measurements were performed before and after drug administration on both study days. Results: Placebo had no effect on TRBF, retinal arterial or venous oxygen content, and retinal oxygen extraction (P > 0.1 each). In contrast, dronabinol induced a significant increase in TRBF from 38.9 ± 6.1 to 40.7 ± 6.7 μL/min (P < 0.001), which was accompanied by a significant increase in retinal venous oxygen content (from 0.129 ± 0.008 to 0.132 ± 0.009 mL O2/mL, P = 0.02). As no change in retinal arterial oxygen content occurred (P = 0.12), retinal oxygen extraction remained stable (2.2 ± 0.4 μL vs. 2.2 ± 0.4 μL O2/min, P = 0.29). Conclusions: These results indicate that orally administered dronabinol increases TRBF in healthy subjects without altering retinal oxygen extraction. The drug may therefore be a candidate for improving perfusion in patients with ocular vascular disease. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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