PHoral: Effects of carnosine supplementation on quantity/quality of oral salivae in healthy volunteer and in subjects affected by common oral pathologies.
Background: Diseases of the oral cavity (OC) with an infectious trigger such as caries and periodontal disease are extremely common in the general population and can also have effects at the cardiovascular level. The oral salivary flow, with its buffering capacity, is able to regulate the pH of the...
| Publicado en: | Medicine Vol. 100; no. 25; pp. 1 - 6 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
6/25/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151672914&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151672914 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00257974 2S6 jtl: Medicine issn: 00257974 maglogo: N pubinfo: dt: 6/25/2021 vid: 100 iid: 25 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 151672914 151672914 NLM34160409 10.1097/MD.0000000000026369 NLM34160409 151672914 ppf: 1 ppct: 5 formats: tig: atl: PHoral: Effects of carnosine supplementation on quantity/quality of oral salivae in healthy volunteer and in subjects affected by common oral pathologies. aug: au: Ciulla, Michele M. Dino Re Gilardoni, Ettore D'Amato, Alfonsina Altomare, Alessandra Baron, Giovanna Carugo, Stefano Aldini, Giancarlo Re, Dino affil: Laboratory of Clinical Informatics and Cardiovascular Imaging, Istituto Stomatologico Italiano, Aesthetic Dentistry, School of DentistryUniversity of Milan, Milan, Italy sug: subj: Dental Caries Diet Therapy Gingivitis Diet Therapy Periodontitis Diet Therapy Saliva Dietary Supplements Adult Cardiovascular Diseases Prevention and Control Periodontitis Microbiology Tablets Microbiologic Phenomena Physiology Gingivitis Prevention and Control Research Subjects Gingivitis Microbiology Young Adult Dental Caries Prevention and Control Male Hydrogen-Ion Concentration Mouth Mucosa Microbiology Dental Caries Complications Administration, Buccal Periodontitis Prevention and Control Adolescence Cardiovascular Diseases Etiology Saliva Metabolism Ferrans and Powers Quality of Life Index Questionnaires Adult: 19-44 years Adolescent: 13-18 years Male ab: Background: Diseases of the oral cavity (OC) with an infectious trigger such as caries and periodontal disease are extremely common in the general population and can also have effects at the cardiovascular level. The oral salivary flow, with its buffering capacity, is able to regulate the pH of the OC and, therefore, significantly contribute to the ecological balance of the microenvironment in which the oral microbiome (OM) develops. On the other side, when the quality/quantity of salivary flow is altered it is supposed the disruption of this balance with the potential increase in oral pathogens and triggered diseases. Among the endogenous substances able to exert a significant effect on the salivary flow and its characteristics, carnosine (Car), a dipeptide originally isolated in skeletal muscle, represents, thanks to the known buffering properties, a promising principle.Methods: We aimed this protocol to evaluate the quantitative/qualitative characteristics of the salivary flow in healthy volunteer subjects (n = 20) and in subjects suffering from common OC pathologies (n = 40), before and after 7 days of supplementation with SaliflussTM (Metis Healthcare srl, Milan, Italy), a Class I medical device on the market as 400 mg mucoadhesive oral tablets that has Car as the main ingredient.Discussion: Combining the characteristics of saliva with the OM and comparing them with OC pathologies, we expect to clarify their reciprocal relationship and, using quantitative proteomics techniques, to help clarify the mechanism of action of Car. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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