Inter-week variation of meibometry and tear break-up time in healthy subjects.
Clinical Relevance: Variation with time in the tear film parameters should be considered by the clinician since the time when measurements are made can influence proper diagnosis.Background: A hallmark of dry eye is an unstable tear film associated with variability in objective daily measures. The p...
| Publicado en: | Clinical & Experimental Optometry Vol. 104; no. 6; pp. 691 - 698 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151679606&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151679606 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08164622 1CKN jtl: Clinical & Experimental Optometry issn: 08164622 maglogo: N pubinfo: dt: Nov2021 vid: 104 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 151679606 151679606 NLM33689665 151679606 10.1080/08164622.2021.1878815 NLM33689665 151679606 ppf: 691 ppct: 7 formats: tig: atl: Inter-week variation of meibometry and tear break-up time in healthy subjects. aug: au: Garcia-Queiruga, Jacobo Pena-Verdeal, Hugo Giraldez, Maria Jesus Garcia-Resua, Carlos Yebra-Pimentel, Eva affil: Department of Applied Physics (Optometry Section), University of Santiago de Compostela, Galicia, Spain sug: subj: Tears Dry Eye Syndromes Diagnosis Fluorescent Dyes Research Subjects Human Blinking Comparative Studies Multicenter Studies Evaluation Research Validation Studies ab: Clinical Relevance: Variation with time in the tear film parameters should be considered by the clinician since the time when measurements are made can influence proper diagnosis.Background: A hallmark of dry eye is an unstable tear film associated with variability in objective daily measures. The purpose of the present study was to evaluate the inter-week repeatability of meibometry, break-up time (BUT) and maximum blink interval (MBI) in healthy subjects.Methods: Forty healthy subjects were recruited for the study. Meibometry, BUT and MBI were performed twice in two sessions, one-week apart. Meibum from the lower eyelid was collected and quantified with the Meibometer MB550. Five meibomian curves were generated by tape and each peak value was averaged as a mean value per session. BUT and MBI were determined three times after fluorescein instillation and recorded by a DV-3 camera attached to the slit lamp. BUT and MBI videos were analysed by a second masked observer. Both BUT and MBI values were calculated by averaging the two most similar measurements of the three evaluated.Results: No statistical difference between inter-week sessions was obtained for the meibometry (p > 0.340; Wilcoxon test), BUT (p > 0.326; Wilcoxon test) and MBI values (p ≥ 0.248; Wilcoxon test). Inter-week differences were low for BUT and MBI when time intervals were no longer than 15 seconds (both p ≥ 0.586; Wilcoxon test). A correlation between BUT and MBI was found (r ≥ 0.668, p < 0.001; Spearman Rho), while a no statistical correlation was obtained between meibometry results and BUT or MBI (all p ≥ 0.194; Spearman Rho).Conclusion: Meibum secretion and the tear film stability present good intersession repeatability, and are stable along with sessions in healthy patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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