Working Overtime: Altered Functional Connectivity in Working Memory Following Regular Cannabis Use in Young Adults.
There is an emerging consensus that regular cannabis use may be detrimental to the developing brain, including potential long-lasting changes in executive functioning. Consequently, the present study examined neural activation and performance on a working memory n-back task using functional magnetic...
| Publicado en: | International Journal of Mental Health & Addiction Vol. 19; no. 4; pp. 1314 - 1330 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Springer Nature
Aug2021
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=151759677&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 151759677 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 15571874 46AW jtl: International Journal of Mental Health & Addiction issn: 15571874 maglogo: N pubinfo: dt: Aug2021 vid: 19 iid: 4 pid: 237 pub: Springer Nature artinfo: ui: 151759677 10.1007/s11469-020-00226-y ppf: 1314 ppct: 16 formats: fmt: @attributes: type: P size: 1.5MB tig: atl: Working Overtime: Altered Functional Connectivity in Working Memory Following Regular Cannabis Use in Young Adults. aug: au: Hatchard, Taylor Byron-Alhassan, Aziza Mioduszewski, Ola Holshausen, Katherine Correia, Stacey Leeming, Allison Ayson, Gladys Chiasson, Carley Fried, Peter Cameron, Ian Smith, Andra affil: School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, K1N-6N5, Ottawa, ON, Canada Department of Psychology, St. Joseph's Healthcare Hamilton, 100 West 5th Street, Hamilton, ON, Canada Department of Psychology, Carleton University, 1125 Colonel By Drive, K1S-1S2, Ottawa, ON, Canada Department of Diagnostic Imaging, The Ottawa Hospital, 1053 Carling Ave, K1Y-4E9, Ottawa, ON, Canada su: Young adults Marijuana Memory Functional connectivity Short-term memory Functional magnetic resonance imaging sug: subj: Young adults Marijuana Memory All other miscellaneous crop farming Functional connectivity Short-term memory Functional magnetic resonance imaging keyword: Cannabis fMRI Working memory Cannabis fMRI Working memory ab: There is an emerging consensus that regular cannabis use may be detrimental to the developing brain, including potential long-lasting changes in executive functioning. Consequently, the present study examined neural activation and performance on a working memory n-back task using functional magnetic resonance imaging (fMRI) in a sample of young adults (ages 19 to 21) from a longitudinal research sample. Regular cannabis users (n = 10) were compared with non-regular cannabis user controls (n = 14) while completing the letter n-back task during fMRI. While there were no differences across performance indices, imaging parameters showed significant differences in brain activation during task performance. Specifically, there was evidence of increased activation in the left and right temporal lobes and the right superior frontal cortex in cannabis users, including significantly altered functional connectivity between these areas. Functional connectivity analyses also showed differences in expected patterns of connectivity in both working memory and reward circuitries among cannabis users, possibly reflecting compensatory mechanisms as a result of sustained use. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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