Clinical Utility of a Reaction-Time Attention Task in the Evaluation of Cognitive Impairment in Elderly with High Educational Disparity.
Background: The Clinical Dementia Rating (CDR) scale is commonly used to stage cognitive impairment, despite having educational limitations. In elderly with low education, a previous study has shown that intraindividual variability of reaction time (CV) and commission errors (CE), measured using a c...
| Publicado en: | Journal of Alzheimer's Disease Vol. 81; no. 2; pp. 691 - 698 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Sage Publications Inc.
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151821085&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151821085 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872877 FLR jtl: Journal of Alzheimer's Disease issn: 13872877 maglogo: N pubinfo: dt: 2021 vid: 81 iid: 2 pid: 20732 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 151821085 151821085 NLM33814451 151821085 10.3233/JAD-210151 NLM33814451 151821085 ppf: 691 ppct: 7 formats: tig: atl: Clinical Utility of a Reaction-Time Attention Task in the Evaluation of Cognitive Impairment in Elderly with High Educational Disparity. aug: au: Schmidt, Sergio L. Boechat, Yolanda Eliza Moreira Schmidt, Guilherme J. Nicaretta, Denise van Duinkerken, Eelco Schmidt, Juliana J. affil: Department of Neurology, Federal University of The State of Rio de Janeiro, Rio de Janeiro, Brazil sug: subj: Cognition Disorders Physiopathology Alzheimer's Disease Physiopathology Task Performance and Analysis Attention Alzheimer's Disease Diagnosis Severity of Illness Indices Male Cognition Disorders Diagnosis Cognition Female Disease Progression Human Aged Educational Status Aged, 80 and Over Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales Aged: 65+ years Aged, 80 & over Male Female ab: Background: The Clinical Dementia Rating (CDR) scale is commonly used to stage cognitive impairment, despite having educational limitations. In elderly with low education, a previous study has shown that intraindividual variability of reaction time (CV) and commission errors (CE), measured using a culture-free Go/No-Go task, can reliably distinguish early Alzheimer's disease (AD) from mild cognitive impairment (MCI) and healthy controls.Objective: We aimed to extend the clinical utility of this culture-free Go/No-Go task in a sample with high educational disparity.Methods: One hundred and ten participants with a wide range of years of formal education (0-14 years) were randomly selected from a geriatric unit and divided based on their CDR scores into cognitively unimpaired (CDR = 0), MCI (CDR = 0.5), and early AD (CDR = 1). All underwent a 90-s reaction-time test that measured the variables previously found to predict CDR in low educated elderly. Here we added years of formal education (educational level) to the model. Multivariate analyses compared differences in group means using educational level as confounding factor. A confirmatory discriminant analyses was performed, to assess if CDR scores could be predicted by the two Go/No-Go variables in a sample with high educational disparity.Results: Over all three groups, differences in both CE and CV reached statistical significance (p < 0.05). The discriminant analysis demonstrated that CV and CE discriminated cognitively impaired from cognitively normal elderly. These results remained similar when discriminating MCI from cognitively unimpaired elderly.Conclusion: The Go/No-Go task reliably discriminates elderly with MCI from elderly without cognitive impairment independent of educational disparity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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