Similar dietary regulation of IGF-1- and IGF-binding proteins by animal and plant protein in subjects with type 2 diabetes.
Increased animal but not plant protein intake has been associated with increased mortality in epidemiological studies in humans and with reduced lifespan in animal species. Protein intake increases the activity of the IGF-1 system which may provide a link to reduced lifespan. We, therefore, compared...
| Published in: | European Journal of Nutrition Vol. 60; no. 6; pp. 3499 - 3505 |
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| Main Authors: | , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Sep2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151838157&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151838157 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2021 vid: 60 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 151838157 149118881 151838157 151838157 10.1007/s00394-021-02518-y 151838157 ppf: 3499 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Similar dietary regulation of IGF-1- and IGF-binding proteins by animal and plant protein in subjects with type 2 diabetes. aug: au: Schüler, Rita Markova, Mariya Osterhoff, Martin A. Arafat, Ayman Pivovarova, Olga Machann, Jürgen Hierholzer, Johannes Hornemann, Silke Rohn, Sascha Pfeiffer, Andreas F. H. affil: Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), 14558, Nuthetal, Germany sug: subj: Plant Proteins Animal Proteins, Dietary Somatomedins Blood Diabetes Mellitus, Type 2 Self Regulation Blood Glucose Human Insulin Resistance Biological Markers Phenotype Dietary Fats Carbohydrates Insulin Metabolism Amino Acids ab: Increased animal but not plant protein intake has been associated with increased mortality in epidemiological studies in humans and with reduced lifespan in animal species. Protein intake increases the activity of the IGF-1 system which may provide a link to reduced lifespan. We, therefore, compared the effects of animal versus plant protein intake on circulating levels of IGF-1 and the IGF-binding proteins (IGFBP)-1 and IGFBP-2 over a 6-week period. Thirty seven participants with type 2 diabetes consumed isocaloric diets composed of either 30% energy (EN) animal or plant protein, 30% EN fat and 40% EN carbohydrates for 6 weeks. The participants were clinically phenotyped before and at the end of the study. Both diets induced similar and significant increases of IGF-1 which was unaffected by the different amino acid compositions of plant and animal protein. Despite improvements of insulin sensitivity and major reductions of liver fat, IGFBP2 decreased with both diets while IGFBP-1 was not altered. We conclude that animal and plant protein similarly increase IGF-1 bioavailability while improving metabolic parameters and may be regarded as equivalent in this regard. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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