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Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film.

Micro-reservoir based drug delivery systems have the potential to provide targeted drug release locally in the intestine, i.e. at the inflamed areas of the intestine of patients with inflammatory bowel disease (IBD). In this study, microcontainers with a diameter of 300 µm and a height of 100 µm, as...

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Published in:Biomedical Microdevices Vol. 23; no. 3; pp. 1 - 12
Main Authors: Abid, Zarmeena, Andreoli, Francesca, Kristensen, Maja N., Petersen, Ritika S., Müllertz, Anette, Boisen, Anja, Keller, Stephan S.
Format: Journal Article
Published: Springer Nature Sep2021
Online Access:View this record in EBSCOhost
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      dt: Sep2021
      vid: 23
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      pub: Springer Nature
      place: New York, New York
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        151900294
        10.1007/s10544-021-00572-1
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        atl: Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film.
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          Abid, Zarmeena
          Andreoli, Francesca
          Kristensen, Maja N.
          Petersen, Ritika S.
          Müllertz, Anette
          Boisen, Anja
          Keller, Stephan S.
        affil: The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Technical University of Denmark, 2800, Kgs. Lyngby, Denmark
      sug:
      ab: Micro-reservoir based drug delivery systems have the potential to provide targeted drug release locally in the intestine, i.e. at the inflamed areas of the intestine of patients with inflammatory bowel disease (IBD). In this study, microcontainers with a diameter of 300 µm and a height of 100 µm, asymmetrical geometry and the possibility to provide unidirectional release, are fabricated in the biodegradable polymer poly-ɛ-caprolactone (PCL) using hot punching. As a first step towards local treatment of IBD, a novel method for loading of microcontainers with the corticosteroid budesonide is developed. For this purpose, a budesonide-Soluplus drug-polymer film is prepared by spin coating and loaded into the microcontainer reservoirs using hot punching. The processing parameters are optimized to achieve a complete loading of a large number of containers in a single step. A poly(lactic-co-glycolic acid) (PLGA) 50:50 lid is subsequently applied by spray coating. Solid-state characterization indicates that the drug is in an amorphous state in the drug-polymer films and the in vitro drug release profile showed a 68% release over 10 h. The results demonstrate that hot punching can be employed both as a production and loading method for PCL microcontainers with the perspective of local treatment of IBD.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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