Inertial microfluidics: Determining the effect of geometric key parameters on capture efficiency along with a feasibility evaluation for bone marrow cells sorting.
Despite great developments in inertial microfluidics, there is still a lack of knowledge to precisely define the particles' behavior in the microchannels. In the present study, as a prerequisite to experimental studies, numerical simulations have been used to study the capture efficiency of target p...
| Publicado en: | Biomedical Microdevices Vol. 23; no. 3; pp. 1 - 13 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151900299&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151900299 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872176 ODN jtl: Biomedical Microdevices issn: 13872176 maglogo: N pubinfo: dt: Sep2021 vid: 23 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 151900299 10.1007/s10544-021-00577-w 151900299 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Inertial microfluidics: Determining the effect of geometric key parameters on capture efficiency along with a feasibility evaluation for bone marrow cells sorting. aug: au: Ghadiri, Mohammad Mahdi Hosseini, Seied Ali Sadatsakkak, Seyed abbas Rajabpour, Ali affil: Department of Mechanical Engineering, Imam Khomeini International University, Qazvin, Iran sug: ab: Despite great developments in inertial microfluidics, there is still a lack of knowledge to precisely define the particles' behavior in the microchannels. In the present study, as a prerequisite to experimental studies, numerical simulations have been used to study the capture efficiency of target particles in the contraction–expansion microchannel, aiming to provide an estimation of the conditions at which the channel performs best. Fluid analysis based on Navier–Stokes equations is conducted using the finite element method to determine the streamlines and vortices. The highest capture efficiency for 10, 15, and 19-micron particles occurs when the center of the vortex is approximately in the middle of the wide section (at the flow rate of 0.35 ml/min). In addition to investigating the effect of particle diameter and input flow rate, the effect of channel geometry parameters (channel height and initial length of the channel) on particle trapping has also been studied. Also, to consider great interest in separating different-sized bioparticles from a sample, a three-stage platform has been designed to separate four types of bone marrow cells and evaluate the possibility of using contraction–expansion channels in this application. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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