Modeling Time to Death of Patients with Multidrug-Resistant Tuberculosis at Saint Peter's Specialized Hospital.
Background: Currently, the worldwide prevalence and incidence of multidrug-resistant tuberculosis (MDR-TB) is drastically increasing. The main objective of this study was modeling the time-to-death of patients with MDR-TB at St. Peter's Specialized Hospital, Addis Ababa, Ethiopia, by using various p...
| Publicado en: | Journal of Research in Health Sciences Vol. 21; no. 2; pp. 1 - 9 |
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| Autores principales: | , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Hamadan University of Medical Sciences, School of Public Health
Spring2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=151914910&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 151914910 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22287795 903Q jtl: Journal of Research in Health Sciences issn: 22287795 maglogo: N pubinfo: dt: Spring2021 vid: 21 iid: 2 pid: 54266 pub: Hamadan University of Medical Sciences, School of Public Health artinfo: ui: 151914910 151914910 151914910 10.34172/jrhs.2021.50 151914910 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Modeling Time to Death of Patients with Multidrug-Resistant Tuberculosis at Saint Peter's Specialized Hospital. aug: au: Wotale, Teramaj Wongel Terefe, Abiyot Negash Fufa, Jaleta Abdisa sug: subj: Tuberculosis, Multidrug-Resistant Hospitals, Special Ethiopia Time Death Human Retrospective Design Rural Areas Descriptive Statistics Ethiopia ab: Background: Currently, the worldwide prevalence and incidence of multidrug-resistant tuberculosis (MDR-TB) is drastically increasing. The main objective of this study was modeling the time-to-death of patients with MDR-TB at St. Peter's Specialized Hospital, Addis Ababa, Ethiopia, by using various parametric shared frailty models. Study Design: A retrospective study design was used. Methods: The study population was TB patients with MDR at St. Peter's Specialized Hospital from January 2016 through December 2019. Exponential, Weibull, and log-normal were used as baseline hazard functions with the gamma and inverse Gaussian frailty distributions. All the models were compared based on Akaike's Information Criteria. Results: The overall median time to death was 11 months and 123 (33.5%) patients died. Patients who lived in rural areas had shorter survival time than those who lived in urban areas with an accelerated factor of 0.135 (P=0.002). Patients with a history of anti-TB drug consumption had a short survival time than those without such a history with an accelerated factor of 0.02 (P=0.001). The variability (heterogeneity) of time to death of patients in the region for the selected model (Weibull-inverse Gaussian shared frailty model) was θ=0.144 (P=0.027). Conclusion: The MDR-TB patients with weight gain, khat and alcohol consumption, clinical complication of pneumothorax and pneumonia, extrapulmonary TB, and history of anti-TB drug consumption as well as those who lived in rural areas had a shorter survival time, compared to others. There was a significant heterogeneity effect in the St. Peter's Specialized Hospital. The best model for predicting the time to death of MDR-TB patients was Weibull-inverse Gaussian shared frailty model. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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