Utility of the "2019 ACR/EULAR classification criteria" for the management of patients with IgG4-related disease.
• The 2019 ACR/EULAR Classification criteria for IgG4-RD represent a replicable instrument for classifying patients. • The 2019 ACR/EULAR Classification criteria for IgG4-RD provide a useful framework for orienting diagnosis. • The 2019 ACR/EULAR Classification criteria for IgG4-RD do not predict di...
| Publicado en: | Seminars in Arthritis & Rheumatism Vol. 51; no. 4; pp. 761 - 766 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
W B Saunders
Aug2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152003392&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152003392 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00490172 4GQ jtl: Seminars in Arthritis & Rheumatism issn: 00490172 maglogo: N pubinfo: dt: Aug2021 vid: 51 iid: 4 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 152003392 152003392 152003392 10.1016/j.semarthrit.2021.04.021 152003392 ppf: 761 ppct: 5 formats: tig: atl: Utility of the "2019 ACR/EULAR classification criteria" for the management of patients with IgG4-related disease. aug: au: Della-Torre, Emanuel Lanzillotta, Marco Germanò, Tommaso Mancuso, Gaia Ramirez, Giuseppe Alvise Capurso, Gabriele Falconi, Massimo Dagna, Lorenzo affil: Università Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy sug: subj: Immunoglobulin G4-Related Disease Classification Immunoglobulin G4-Related Disease Diagnosis Patient Classification Immunoglobulin G4-Related Disease Therapy Biological Markers Eosinophils Conceptual Framework Research Subject Recruitment Inflammation Diabetes Mellitus Osteoporosis Recurrence Human ab: • The 2019 ACR/EULAR Classification criteria for IgG4-RD represent a replicable instrument for classifying patients. • The 2019 ACR/EULAR Classification criteria for IgG4-RD provide a useful framework for orienting diagnosis. • The 2019 ACR/EULAR Classification criteria for IgG4-RD do not predict disease outcomes. The 2019 ACR/EULAR Classification Criteria for IgG4-related disease (IgG4-RD) represent a fundamental tool for patient enrollment in research studies and in clinical trials but their usefulness in daily clinical practice remains unknown. To validate the 2019 ACR/EULAR Classification Criteria for IgG4-RD in a real-life setting and to anticipate their utility for orienting disease diagnosis and patient management. Four experts were asked to classify 200 patients diagnosed with IgG4-RD according to the 2019 ACR/EULAR Classification Criteria for IgG4-RD. Agreement between experts was calculated and the Classification score of each patient was correlated with the following variables and outcomes: serum IgG4 and IgE; inflammatory markers; eosinophils; plasmablasts; IgG4-RD responder index; diabetes, osteoporosis, relapses; and use of rituximab. Among the 157/200 cases equally rated by at least three experts, 94 (59.9%) achieved IgG4-RD classification and 63 (40.1%) did not. Strong agreement among IgG4-RD experts was observed in classifying patients (k = 0.711, p <0.0001). Clinical presentations not included in the classification algorithm and lack of informative histology were the most common reasons for not achieving classification. In patients achieving classification, the Classification score did not correlate with variables of disease activity and was not associated with specific outcomes. The ACR/EULAR Classification Criteria represent a replicable instrument for classifying patients and a useful framework for orienting diagnosis but are of limited utility for assessing IgG4-RD activity, for predicting disease outcomes, and for defining personalized therapeutic approaches. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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