The VNTR of the AS3MT gene is associated with brain activations during a memory span task and their training-induced plasticity.
Background: The Arsenic (+3 oxidation state) methyltransferase (AS3MT) gene has been identified as a top risk gene for schizophrenia in several large-scale genome-wide association studies. A variable number tandem repeat (VNTR) of this gene is the most significant expression quantitative trait locus...
| Publicado en: | Psychological Medicine Vol. 51; no. 11; pp. 1927 - 1933 |
|---|---|
| Autores principales: | , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Aug2021
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152012903&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152012903 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Aug2021 vid: 51 iid: 11 pid: 15979 pub: Cambridge University Press artinfo: ui: 152012903 152012903 152012903 10.1017/S0033291720000720 152012903 ppf: 1927 ppct: 6 formats: tig: atl: The VNTR of the AS3MT gene is associated with brain activations during a memory span task and their training-induced plasticity. aug: au: Zhao, Wan Zhang, Qiumei Chen, Xiongying Li, Yang Li, Xiaohong Du, Boqi Deng, Xiaoxiang Ji, Feng Wang, Chuanyue Xiang, Yu-Tao Dong, Qi Chen, Chuansheng Li, Jun affil: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China sug: subj: Memory Education Task Performance and Analysis Brain Physiology Genome, Human Arsenic Metabolism Transferases Metabolism Oxidation-Reduction Gene Expression Evaluation Neuronal Plasticity Human In Vivo Studies Brain Radiography Magnetic Resonance Imaging Methods Pretest-Posttest Design ab: Background: The Arsenic (+3 oxidation state) methyltransferase (AS3MT) gene has been identified as a top risk gene for schizophrenia in several large-scale genome-wide association studies. A variable number tandem repeat (VNTR) of this gene is the most significant expression quantitative trait locus, but its role in brain activity in vivo is still unknown. Methods: We first performed a functional magnetic resonance imaging (fMRI) scan of 101 healthy subjects during a memory span task, trained all subjects on an adaptive memory span task for 1 month, and finally performed another fMRI scan after the training. After excluding subjects with excessive head movements for one or more scanning sessions, data from 93 subjects were included in the final analyses. Results: The VNTR was significantly associated with both baseline brain activation and training-induced changes in multiple regions including the prefrontal cortex and the anterior and posterior cingulate cortex. Additionally, it was associated with baseline brain activation in the striatum and the parietal cortex. All these results were corrected based on the family-wise error rate method across the whole brain at the peak level. Conclusions: This study sheds light on the role of AS3MT gene variants in neural plasticity related to memory span training. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|