Changes in pulse waveforms in response to intraocular pressure elevation determined by laser speckle flowgraphy in healthy subjects.
Background: The influences of intraocular pressure (IOP) elevations on the pulse waveform in the optic nerve head (ONH) were evaluated using laser speckle flowgraphy (LSFG) in normal subjects.Methods: This prospective cross-sectional study was conducted at the Nagoya University Hospital. An ophthalm...
| Publicado en: | BMC Ophthalmology Vol. 21; no. 1; pp. 1 - 14 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
8/21/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152026332&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152026332 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712415 1CIB jtl: BMC Ophthalmology issn: 14712415 maglogo: N pubinfo: dt: 8/21/2021 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 152026332 152026332 NLM34416871 10.1186/s12886-021-02070-7 NLM34416871 152026332 ppf: 1 ppct: 13 formats: tig: atl: Changes in pulse waveforms in response to intraocular pressure elevation determined by laser speckle flowgraphy in healthy subjects. aug: au: Iwase, Chie Iwase, Takeshi Tomita, Ryo Akahori, Tomohiko Yamamoto, Kentaro Ra, Eimei Terasaki, Hiroko affil: Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan sug: subj: Optic Nerve Intraocular Pressure Research Subjects Blood Pressure Diagnosis, Cardiovascular Cross Sectional Studies Blood Flow Velocity Blood Circulation Prospective Studies Lasers Clinical Assessment Tools ab: Background: The influences of intraocular pressure (IOP) elevations on the pulse waveform in the optic nerve head (ONH) were evaluated using laser speckle flowgraphy (LSFG) in normal subjects.Methods: This prospective cross-sectional study was conducted at the Nagoya University Hospital. An ophthalmodynamometer was pressed on the sclera to increase the IOP by 20 mmHg or 30 mmHg for 1 min (experiment 1, 16 subjects) and by 30 mmHg for 10 min (experiment 2, 10 subjects). The mean blur rate (MBR) and the eight pulse waveform parameters determined using LSFG were measured before, immediately after and during an IOP elevation, and after the IOP returned to the baseline pressure.Results: A significant elevation in the IOP and a significant reduction in the ocular perfusion pressure (OPP) were found after applying the ophthalmodynamometer (both, P < 0.001). The blowout score (BOS) reduced significantly (P < 0.001), and the flow acceleration index (FAI; P < 0.01) and resistivity index (RI; P < 0.001) increased significantly immediately after increasing the IOP by 20 or 30 mmHg (experiment 1). The BOS reduced significantly (P < 0.001), and the FAI (P < 0.01) and RI (P < 0.001) increased significantly after the IOP elevation by 30 mmHg in both experiment 2 and 1. However, the BOS and RI recovered significantly at time 10 compared to that in time 0 (immediately after IOP elevation) during the 10-min IOP elevation (P < 0.001 and P = 0.008, respectively).Conclusions: In conclusion, the BOS, FAI, and RI of the pulse waveforms changed significantly with an acute elevation in the IOP. The change should be related to the larger difference between the maximum and minimum MBRs during the IOP elevation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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