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A Potential ceRNA Network for Neurological Damage in Preterm Infants.

Objective. This study is aimed at identifying key genes involved in neurological damage in preterm infants and at determining their potential circRNA-miRNA-mRNA regulatory mechanisms. Methods. Differentially expressed miRNAs, mRNAs, and circRNAs were downloaded from the GEO database. GO and KEGG enr...

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Published in:BioMed Research International pp. 1 - 16
Main Authors: Huang, Jin, Liang, Xuejing, Cai, Zhenyu
Format: research tables/charts Journal Article
Published: Wiley-Blackwell 8/23/2021
Online Access:View this record in EBSCOhost
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        23146133
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      jtl: BioMed Research International
      issn: 23146133
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    pubinfo:
      dt: 8/23/2021
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        152040467
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        152040467
        10.1155/2021/2628824
        152040467
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        atl: A Potential ceRNA Network for Neurological Damage in Preterm Infants.
      aug:
        au:
          Huang, Jin
          Liang, Xuejing
          Cai, Zhenyu
        affil: Department of Obstetrics and Gynecology, Aviation General Hospital of China Medical University, Beijing, China
      sug:
        subj:
          Brain Injuries Familial and Genetic
          Brain Injuries Pathology
          Infant, Premature, Diseases Familial and Genetic
          RNA, Circular Metabolism
          MicroRNA Metabolism
          RNA, Messenger Metabolism
          Gene Expression Profiling
          Bioinformatics
          Human
          Infant, Premature
          Transcription Factors Metabolism
          Gene Expression
          Carrier Proteins Metabolism
          Phosphorylation
          Signal Transduction
          Brain Injuries Diagnosis
          Early Diagnosis
          Infant, Newborn
          Infant, Newborn: birth-1 month
      ab: Objective. This study is aimed at identifying key genes involved in neurological damage in preterm infants and at determining their potential circRNA-miRNA-mRNA regulatory mechanisms. Methods. Differentially expressed miRNAs, mRNAs, and circRNAs were downloaded from the GEO database. GO and KEGG enrichment analyses were used to determine possible relevant functions of differentially expressed mRNAs. The TTRUST database was used to predict differential TF-mRNA regulatory relationships. Then, CircMIR, miRDB, TargetScan and miRTarBase were then used to map circRNA/miRNA-TF/mRNA interaction networks. Finally, GSEA enrichment analysis was performed on the core transcription factors. Results. A total of 640 mRNAs, 139 circRNAs, and 206 differentially expressed miRNAs associated with neurological injury in preterm infants were obtained. Based on the findings of Cytoscape and PPI network analysis, the hsa_circ_0008439-hsa-mir-3665-STAT3-MMP3 regulatory axis was established. GSEA analysis revealed that suppressed expression levels of STAT3 were associated with upregulated oxidative phosphorylation pathways in the neurological injury group of preterm infants. Conclusions. The circRNA-miRNA-TF-mRNA regulatory network of neurological injury in preterm infants can be used to elucidate on the pathogenesis of brain injury and help us with the early detection of brain injury in preterm infants.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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