Quantifying muscle alterations in a Parkinson's disease animal model using electromyographic biomarkers.
Parkinson's disease (PD) is a neurodegenerative disease currently diagnosed based on characteristic motor dysfunctions. The most common Parkinson's disease animal model induces massive nigrostriatal degeneration by intracerebral infusion of 6-hydroxydopamine (6-OHDA). Motor deficits in rat models of...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 59; no. 9; pp. 1735 - 1750 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152044044&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152044044 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Sep2021 vid: 59 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 152044044 151536248 152044044 NLM34297299 10.1007/s11517-021-02400-3 NLM34297299 152044044 ppf: 1735 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Quantifying muscle alterations in a Parkinson's disease animal model using electromyographic biomarkers. aug: au: Teruya, Pablo Y. Farfán, Fernando D. Pizá, Álvaro G. Soletta, Jorge H. Lucianna, Facundo A. Albarracín, Ana L. affil: Laboratorio de Investigaciones en Neurociencias Y Tecnologías Aplicadas (LINTEC), Departamento de Bioingeniería, Facultad de Ciencias Exactas Y Tecnología, Universidad Nacional de Tucumán, Av. Independencia 1800, (4000) San Miguel de Tucumán, Tucumán, Argentina sug: subj: Parkinson Disease Neurodegenerative Diseases Muscles Rats Models, Biological Animals Scales ab: Parkinson's disease (PD) is a neurodegenerative disease currently diagnosed based on characteristic motor dysfunctions. The most common Parkinson's disease animal model induces massive nigrostriatal degeneration by intracerebral infusion of 6-hydroxydopamine (6-OHDA). Motor deficits in rat models of Parkinson's disease were previously addressed in other works. However, an accurate quantification of muscle function in freely moving PD-lesioned rats over time has not been described until now. In this work, we address the muscular activity characterization of a 6-OHDA-lesion model of PD along 6 weeks post-lesion based on spectral and morphological analysis of the signals. Using chronic implanted EMG electrodes in a hindlimb muscle of freely moving rats, we have evaluated the effect of the PD neurotoxic model in the muscular activity during locomotion. EMG signals obtained from animals with different time post-injury were analyzed. Power spectral densities were characterized by the mean and median frequency, and the EMG burst stationarity was previously verified for all animals. Our results show that as the time post-lesion increases both frequency parameters decrease. Probability distribution function analysis was also performed. The results suggest that contractile dynamics of the biceps femoris muscle change with time post-lesion. We have also demonstrated here the usefulness of frequency parameters as biomarkers for monitoring the muscular function changes that could be used for early detection of motor dysfunction. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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