The meaningful change threshold as measured by the 16-item quick inventory of depressive symptomatology in adults with treatment-resistant major depressive and bipolar disorder receiving intravenous ketamine.
Objective: .To identify a meaningful change threshold (MCT) in depression outcomes in adults with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) receiving intravenous ketamine treatment at a community-based mood disorders center.Method: .A triangular approach integratin...
| Published in: | Journal of Affective Disorders Vol. 294; pp. 592 - 597 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Elsevier B.V.
Nov2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152080159&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152080159 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01650327 3M9 jtl: Journal of Affective Disorders issn: 01650327 maglogo: N pubinfo: dt: Nov2021 vid: 294 pid: 1004 pub: Elsevier B.V. artinfo: ui: 152080159 152080159 NLM34332360 152080159 10.1016/j.jad.2021.07.035 NLM34332360 152080159 ppf: 592 ppct: 5 formats: tig: atl: The meaningful change threshold as measured by the 16-item quick inventory of depressive symptomatology in adults with treatment-resistant major depressive and bipolar disorder receiving intravenous ketamine. aug: au: McIntyre, Roger S. Lipsitz, Orly Lui, Leanna M.W. Rodrigues, Nelson B. Gill, Hartej Nasri, Flora Ling, Rui Teopiz, Kayla M. Ho, Roger C. Subramaniapillai, Mehala Kratiuk, Kevin Mansur, Rodrigo B. Jones, Brett D.M. Lee, Yena Rosenblat, Joshua D. affil: Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada sug: subj: Ketamine Therapeutic Use Bipolar Disorder Drug Therapy Depression Drug Therapy Adult Self Report Psychological Tests Human Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales Questionnaires Adult: 19-44 years ab: Objective: .To identify a meaningful change threshold (MCT) in depression outcomes in adults with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) receiving intravenous ketamine treatment at a community-based mood disorders center.Method: .A triangular approach integrating both anchor-based and distributive methods was used to identify meaningful change on the patient-reported Quick Inventory for Depressive Symptoms Self-Report 16-Item (QIDS-SR16) as associated with the Patient Global Impression - Severity (PGI-S). Both the QIDS-SR16 and the PGI-S are self-report measures, and were collected at five timepoints (timepoints were approximately 2-7 days apart).Results: .A total of 297 adults with treatment-resistant depression (TRD) as part of either DSM-5-defined MDD or BD were included. The MCT for the QIDS-SR16 revealed that a mean improvement of 3.38 points from baseline was comparable to a 1-point improvement on the PGI-S. Together with an examination of the probability density function, a 3.5-point change is a reasonable MCT (i.e., 1-point PGI-S improvement) for the QIDS-SR16. A 2-point symptomatic improvement on the QIDS-SR16 was associated with no change on the PGI-S.Conclusion: .A 3.5-point reduction in the QIDS-SR16 represents a MCT based on the PGI-S for adults with treatment-resistant MDD or BD receiving intravenous ketamine treatment at a community-based mood disorders center. These findings are limited by the post-hoc nature of this analysis and open-label case-series design. Measurement-based care decisions by patients, providers and clinicians, as well as cost/reimbursement decisions should include consideration of meaningful change along with conventional objective outcomes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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