Expression of versican mRNA transcript to predict cardiac remodeling after myocardial infarction.
Background: Adverse left-ventricular remodeling (LVR) is defined as a 20% increase in end-diastolic left-ventricular volume 6 months after acute myocardial infarction (AMI). LVR is associated with cardiac dysfunction, therefore deteriorating the prognosis. Aims: We aimed at comparing the concentrati...
| Publicado en: | Polish Heart Journal / Kardiologia Polska Vol. 79; no. 7/8; pp. 833 - 841 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
VM Medica-VM Group (Via Medica)
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152180402&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152180402 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00229032 1CZM jtl: Polish Heart Journal / Kardiologia Polska issn: 00229032 maglogo: N pubinfo: dt: 2021 vid: 79 iid: 7/8 pid: 21698 pub: VM Medica-VM Group (Via Medica) artinfo: ui: 152180402 152180402 152180402 10.33963/KP.a2021.0042 152180402 ppf: 833 ppct: 8 formats: tig: atl: Expression of versican mRNA transcript to predict cardiac remodeling after myocardial infarction. aug: au: Chabior, Aleksandra Gąsecka, Aleksandra Marchel, Michał Gozdowska, Roksana Makowska, Agnieszka Maciak, Karolina Góra, Monika Filipiak, Krzysztof J. Burzyńska, Beata Opolski, Grzegorz affil: 1st Chair and Department of Cardiology, Medical University of Warsaw, Warszawa, Poland sug: subj: RNA, Messenger Blood Ventricular Remodeling Myocardial Infarction Surgery Glycoproteins Human Percutaneous Coronary Intervention Polymerase Chain Reaction Methods Ventricular Ejection Fraction Natriuretic Peptide, Brain ROC Curve Sensitivity and Specificity Multivariate Analysis Multiple Regression Odds Ratio Confidence Intervals ab: Background: Adverse left-ventricular remodeling (LVR) is defined as a 20% increase in end-diastolic left-ventricular volume 6 months after acute myocardial infarction (AMI). LVR is associated with cardiac dysfunction, therefore deteriorating the prognosis. Aims: We aimed at comparing the concentrations of messenger RNA transcripts in the peripheral blood of patients with and without LVR at 6 months. Methods: The study included 75 patients with first ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention. Whole blood concentrations of 6 transcripts were determined 24 hours after AMI using droplet digital polymerase chain reaction. The correlations between mRNA transcript expression and left ventricular ejection fraction (LVEF) and N-terminal-pro B type natriuretic peptide (NT-proBNP) concentration were evaluated. Results: Among 75 patients, 4 were lost to follow-up, and 71 were included in the analysis. Seventeen (24%) patients developed LVR at 6 months. Versican (VCAN) mRNA expression was lower in patients who developed LVR, compared to those who did not (P = 0.02), and discriminated between these patients (area under the ROC curve 67%; P = 0.04). Expression of VCAN transcript <75.3 normalized units predicted LVR with 71% sensitivity and 67% specificity. In a multivariable regression analysis, VCAN expression remained the only independent predictor of LVR (OR 3.475; 95% CI, 1.000-12.075; P = 0.04). Conclusions: Dysregulation of VCAN expression in the acute phase of AMI may contribute to LVR at 6 months. Whether decreased expression of VCAN might be a useful tool to predict LVR in clinical practice remains to be established. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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