Long-term fasting improves lipoprotein-associated atherogenic risk in humans.
Purpose: Dyslipidemia is a major health concern associated with an increased risk of cardiovascular mortality. Long-term fasting (LF) has been shown to improve plasma lipid profile. We performed an in-depth investigation of lipoprotein composition. Methods: This observational study included 40 volun...
| Publicado en: | European Journal of Nutrition Vol. 60; no. 7; pp. 4031 - 4045 |
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| Autores principales: | , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152423265&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152423265 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Oct2021 vid: 60 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 152423265 150193412 152423265 152423265 10.1007/s00394-021-02578-0 152423265 ppf: 4031 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Long-term fasting improves lipoprotein-associated atherogenic risk in humans. aug: au: Grundler, Franziska Plonné, Dietmar Mesnage, Robin Müller, Diethard Sirtori, Cesare R. Ruscica, Massimiliano Wilhelmi de Toledo, Françoise affil: Buchinger Wilhelmi Clinic, Wilhelm-Beck-Straße 27, 88662, Überlingen, Germany sug: subj: Fasting Time Factors Lipoproteins Blood Atherosclerosis Prevention and Control Treatment Outcomes Human Nonexperimental Studies Male Female Adult Middle Age Aged Centrifugation Magnetic Resonance Imaging Triglycerides Lipoproteins, LDL Magnetic Resonance Spectroscopy Lipoproteins, HDL Apolipoproteins Fibrinogen C-Reactive Protein Clinical Trials Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: Dyslipidemia is a major health concern associated with an increased risk of cardiovascular mortality. Long-term fasting (LF) has been shown to improve plasma lipid profile. We performed an in-depth investigation of lipoprotein composition. Methods: This observational study included 40 volunteers (50% men, aged 32–65 years), who underwent a medically supervised fast of 14 days (250 kcal/day). Changes in lipid and lipoprotein levels, as well as in lipoprotein subclasses and particles, were measured by ultracentrifugation and nuclear magnetic resonance (NMR) at baseline, and after 7 and 14 fasting days. Results: The largest changes were found after 14 fasting days. There were significant reductions in triglycerides (TG, − 0.35 ± 0.1 mmol/L), very low-density lipoprotein (VLDL)-TG (− 0.46 ± 0.08 mmol/L), VLDL-cholesterol (VLDL-C, − 0.16 ± 0.03 mmol/L) and low-density lipoprotein (LDL)-C (− 0.72 ± 0.14 mmol/L). Analysis of LDL subclasses showed a significant decrease in LDL1-C (− 0.16 ± 0.05 mmol/L), LDL2-C (− 0.30 ± 0.06 mmol/L) and LDL3-C (− 0.27 ± 0.05 mmol/L). NMR spectroscopy showed a significant reduction in large VLDL particles (− 5.18 ± 1.26 nmol/L), as well as large (− 244.13 ± 39.45 nmol/L) and small LDL particles (− 38.45 ± 44.04 nmol/L). A significant decrease in high-density lipoprotein (HDL)-C (− 0.16 ± 0.04 mmol/L) was observed. By contrast, the concentration in large HDL particles was significantly raised. Apolipoprotein A1 decreased significantly whereas apolipoprotein B, lipoprotein(a), fibrinogen and high-sensitivity C-reactive protein were unchanged. Conclusion: Our results suggest that LF improves lipoprotein levels and lipoprotein subclasses and ameliorates the lipoprotein-associated atherogenic risk profile, suggesting a reduction in the cardiovascular risk linked to dyslipidemia. Trial Registration: Study registration number: DRKS-ID: DRKS00010111 Date of registration: 03/06/2016 "retrospectively registered". pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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