Quantitative Study of the Changes in Cerebral Blood Flow and Iron Deposition During Progression of Alzheimer's Disease.
Background: Advanced Alzheimer's disease (AD) has no effective treatment, and identifying early diagnosis markers can provide a time window for treatment.Objective: To quantify the changes in cerebral blood flow (CBF) and iron deposition during progression of AD.Methods: 94 subjects underwent brain...
| Publicado en: | Journal of Alzheimer's Disease Vol. 78; no. 1; pp. 439 - 453 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Sage Publications Inc.
2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152550865&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152550865 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872877 FLR jtl: Journal of Alzheimer's Disease issn: 13872877 maglogo: N pubinfo: dt: 2020 vid: 78 iid: 1 pid: 20732 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 152550865 152550865 NLM32986675 152550865 10.3233/JAD-200843 NLM32986675 152550865 ppf: 439 ppct: 14 formats: tig: atl: Quantitative Study of the Changes in Cerebral Blood Flow and Iron Deposition During Progression of Alzheimer's Disease. aug: au: Li, Dongxue Liu, Yuancheng Zeng, Xianchun Xiong, Zhenliang Yao, Yuanrong Liang, Daiyi Qu, Hao Xiang, Hui Yang, Zhenggui Nie, Lisha Wu, Pu-Yeh Wang, Rongpin affil: Department of Radiology, Guizhou Provincial People's Hospital, Key Laboratory of Intelligent Medical Imaging Analysis and Accurate Diagnosis of Guizhou Province, International Exemplary Cooperation Base of Precision Imaging for Diagnosis and Treatment, Guiyang, China sug: subj: Cerebrovascular Circulation Alzheimer's Disease Physiopathology Iron Metabolism Aged Magnetic Resonance Imaging Male Disease Progression Human Brain Physiopathology Brain Mapping Female Free Radicals Aged, 80 and Over Middle Age Comparative Studies Multicenter Studies Evaluation Research Validation Studies Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Male Female ab: Background: Advanced Alzheimer's disease (AD) has no effective treatment, and identifying early diagnosis markers can provide a time window for treatment.Objective: To quantify the changes in cerebral blood flow (CBF) and iron deposition during progression of AD.Methods: 94 subjects underwent brain imaging on a 3.0-T MRI scanner with techniques of three-dimensional arterial spin labeling (3D-ASL) and quantitative susceptibility mapping (QSM). The subjects included 22 patients with probable AD, 22 patients with mild cognitive impairment (MCI), 25 patients with subjective cognitive decline (SCD), and 25 normal controls (NC). The CBF and QSM values were obtained using a standardized brain region method based on the Brainnetome Atlas. The differences in CBF and QSM values were analyzed between and within groups using variance analysis and correlation analysis.Results: CBF and QSM identified several abnormal brain regions of interest (ROIs) at different stages of AD (p < 0.05). Regionally, the CBF values in several ROIs of the AD and MCI subjects were lower than for NC subjects (p < 0.001). Higher QSM values were observed in the globus pallidus. The CBF and QSM values in multiple ROI were negatively correlated, while the putamen was the common ROI of the three study groups (p < 0.05). The CBF and QSM values in hippocampus were cross-correlated with scale scores during the progression of AD (p < 0.05).Conclusion: Iron deposition in the basal ganglia and reduction in blood perfusion in multiple regions existed during the progression of AD. The QSM values in putamen can be used as an imaging biomarker for early diagnosis of AD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|