Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation.
Rationale: Reward-associated cues can trigger incentive motivation for reward and invigorate reward-seeking behaviour via Pavlovian-to-instrumental transfer (PIT). Glutamate signaling within the basolateral amygdala (BLA) modulates cue-triggered increases in incentive motivation. However, the role o...
| Publicado en: | Psychopharmacology Vol. 238; no. 10; pp. 2905 - 2918 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152559568&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152559568 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Oct2021 vid: 238 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 152559568 151246941 10.1007/s00213-021-05907-7 152559568 ppf: 2905 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation. aug: au: Garceau, Caroline Samaha, Anne-Noël Cordahi, Thomas Servonnet, Alice Khoo, Shaun Yon-Seng affil: Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, H3T 1J4, Montréal, QC, Canada sug: ab: Rationale: Reward-associated cues can trigger incentive motivation for reward and invigorate reward-seeking behaviour via Pavlovian-to-instrumental transfer (PIT). Glutamate signaling within the basolateral amygdala (BLA) modulates cue-triggered increases in incentive motivation. However, the role of BLA metabotropic group II glutamate (mGlu2/3) receptors is largely unknown. Objectives: In Experiment 1, we characterized cue-triggered increases in incentive motivation for water reward using the PIT paradigm. In Experiment 2, we assessed the influence of intra-BLA microinjections of the mGlu2/3 receptor agonist LY379268 on this effect. Methods: Water-restricted male Sprague–Dawley rats learned to press a lever for water. Separately, they learned to associate one of two auditory cues with free water. On test days, rats could lever press under extinction conditions (no water), with intermittent, non-contingent CS+ and CS- presentations. In Experiment 1, rats were tested under baseline conditions. In Experiment 2, rats received intra-BLA microinjections of LY379268 (0, 3 and 6 μ g/hemisphere) before testing. Results: Across experiments, CS+, but not CS-, presentations increased water-associated lever pressing during testing, even though responding was reinforced neither by water nor the CS+. Intra-BLA LY379268 abolished both CS+ potentiated pressing on the water-associated lever and CS+ evoked conditioned approach to the site of water delivery. LY379268 did not influence locomotion or instrumental and Pavlovian response rates during intervals between CS presentations or during the CS-, indicating no motor effects. Conclusions: mGlu2/3 receptor activity in the BLA mediates cue-triggered potentiation of incentive motivation for reward, suppressing both cue-induced increases in instrumental pursuit of the reward and anticipatory approach behaviour. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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