Crushed Corticosteroid Tablets in Peristomal Pyoderma Gangrenosum.

BACKGROUND: Peristomal pyoderma gangrenosum (PPG) is a variant of pyoderma gangrenosum (PG). It results from a pathergy response to trauma from effluent from the ostomy or secondary to trauma caused by removal of the ostomy appliance adhesive in contact with the skin. Currently, no evidence-based gu...

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Publicado en:Journal of Wound, Ostomy & Continence Nursing Vol. 48; no. 5; pp. 460 - 463
Autores principales: Burlando, Martina, Paravisi, Andrea, Bodini, Giorgia, Cozzan, Emanuele, Parodi, Aurora
Formato: case study pictorial Journal Article
Publicado: Lippincott Williams & Wilkins Sep/Oct2021
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Sep/Oct2021
      vid: 48
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      pub: Lippincott Williams & Wilkins
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        atl: Crushed Corticosteroid Tablets in Peristomal Pyoderma Gangrenosum.
      aug:
        au:
          Burlando, Martina
          Paravisi, Andrea
          Bodini, Giorgia
          Cozzan, Emanuele
          Parodi, Aurora
        affil: Policlinico San Martino Hospital, Genova, Italy
      sug:
        subj:
          Pyoderma Gangrenosum Drug Therapy
          Adrenal Cortex Hormones Therapeutic Use
          Adrenal Cortex Hormones Administration and Dosage
          Adult
          Female
          Treatment Failure
          Adalimumab
          Adult: 19-44 years
          Female
      ab: BACKGROUND: Peristomal pyoderma gangrenosum (PPG) is a variant of pyoderma gangrenosum (PG). It results from a pathergy response to trauma from effluent from the ostomy or secondary to trauma caused by removal of the ostomy appliance adhesive in contact with the skin. Currently, no evidence-based guidelines for the management of PPG exist. This case study reports a dramatic response to crushed corticosteroid tablets in a patient who proved refractory to first- and second-line treatments of her PPG and several surgeries. CASE: Ms I was a 39-year-old woman with Crohn's disease who underwent several ileostomies, developed PPG, and failed treatment with adalimumab. Her PPG was successfully treated topically with crushed prednisone tablets. CONCLUSION: We found that crushed corticosteroid tablets were an effective treatment of PPG, due to the ability to reduce pain and allow adhesion of the ostomy appliance.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        Journal Article
      ougenre: Article
    language: English
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