Depicting the composition of gut microbiota in children with tic disorders: an exploratory study.
Background: Symptom improvement in children with tic disorder (TD) following fecal microbiota transplantation led us to investigate the gut microbiota in TD. This exploratory study aims to depict the gut microbial profile in patients with TD and explore the impact of dopamine receptor antagonist (DR...
| Publicado en: | Journal of Child Psychology & Psychiatry Vol. 62; no. 10; pp. 1246 - 1255 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Wiley-Blackwell
Oct2021
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=152707135&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 152707135 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00219630 JYY jtl: Journal of Child Psychology & Psychiatry issn: 00219630 maglogo: Y pubinfo: dt: Oct2021 vid: 62 iid: 10 pid: 480 pub: Wiley-Blackwell artinfo: ui: 152707135 10.1111/jcpp.13409 ppf: 1246 ppct: 9 formats: tig: atl: Depicting the composition of gut microbiota in children with tic disorders: an exploratory study. aug: au: Xi, Wenjie Gao, Xuefeng Zhao, Huijun Luo, Xi Li, Jianfeng Tan, Xinjie Wang, Lei Zhao, Jian‐Bo Wang, Jing Yang, Guang Liu, Li‐Ying Wang, Yang‐Yang Peng, Lihua Zou, Li‐Ping Yang, Yunsheng affil: School of Medicine, Nankai University, Tianjin, China Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, China Central Laboratory, Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Shenzhen University General Hospital, Shenzhen, China Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China Department of Pediatrics, Chinese PLA General Hospital, Beijing, China Center for Brain Disorders Research, Capital Medical University, Beijing Institute for Brain Disorders, Beijing, China su: Children Research Statistics Escherichia coli Gut microbiota Metadata Bacteroides Multivariate analysis Random forest algorithms Streptococcus Tic disorders Genomics Data analysis Fecal microbiota transplantation Dopamine antagonists sug: subj: Children Research Statistics Escherichia coli Gut microbiota Metadata Bacteroides Multivariate analysis Random forest algorithms Streptococcus Tic disorders Genomics Data analysis Fecal microbiota transplantation Dopamine antagonists keyword: dopamine receptor antagonists gut microbiota metabolic pathways metagenomics dopamine receptor antagonists gut microbiota metabolic pathways metagenomics ab: Background: Symptom improvement in children with tic disorder (TD) following fecal microbiota transplantation led us to investigate the gut microbiota in TD. This exploratory study aims to depict the gut microbial profile in patients with TD and explore the impact of dopamine receptor antagonist (DRA) drugs on the composition and metabolic function of the gut microbiota. Methods: The gut microbiota were profiled in fecal samples of 49 children with TD and 50 matched healthy controls (HC) using shotgun metagenomic sequencing. A random forest (RF) model was constructed using the gut bacterial species to distinguish TD from HC. Associations between clinical metadata and microbial abundance or function were analyzed using MaAsLin2 and Spearman correlation. Results: The gut microbiota in children with TD was featured by higher abundances of Bacteroides plebeius and Ruminococcus lactaris (a potential pro‐inflammatory taxon) and lower abundances of Prevotella stercorea and Streptococcus lutetiensis compared to HC. The constructed RF model accurately distinguished TD from HC based on the gut microbiota profile, resulting in an AUC of 0.884. Significant correlations were observed between tic symptom severity and the abundances of multiple bacterial species and gut microbiota metabolic functions. Multivariate analysis identified an upregulation of 4‐aminobutanoate (GABA) degradation in the gut microbiota associated with TD status. The gut microbiota of DRA‐treated TD children showed a distinct gut microbiota compared to the treatment‐naïve group, represented by an increase in some potential enteric pathogens such as Escherichia coli, a decline in several species including Akkermansia muciniphila, and alterations in various metabolic functions. Conclusions: Bacterial species promoting inflammatory responses and those modulating neurotransmitters such as GABA may be involved in the pathogenesis of TD. The use of DRA drugs is likely to induce overgrowth of some enteric pathogens and alter the gut microbiota metabolism. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|