PET imaging of neural activity, β-amyloid, and tau in normal brain aging.
Normal brain aging is commonly associated with neural activity alteration, β-amyloid (Aβ) deposition, and tau aggregation, driving a progressive cognitive decline in normal elderly individuals. Positron emission tomography (PET) with radiotracers targeting these age-related changes has been increasi...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 48; no. 12; pp. 3859 - 3872 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152744550&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152744550 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Nov2021 vid: 48 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 152744550 149085914 10.1007/s00259-021-05230-5 152744550 ppf: 3859 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: PET imaging of neural activity, β-amyloid, and tau in normal brain aging. aug: au: Zhang, Kai Mizuma, Hiroshi Zhang, Xiaohui Takahashi, Kayo Jin, Chentao Song, Fahuan Gao, Yuanxue Kanayama, Yousuke Wu, Yuping Li, Yuting Ma, Lijuan Tian, Mei Zhang, Hong Watanabe, Yasuyoshi affil: Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, 650-0047, Kobe, Hyogo, Japan sug: ab: Normal brain aging is commonly associated with neural activity alteration, β-amyloid (Aβ) deposition, and tau aggregation, driving a progressive cognitive decline in normal elderly individuals. Positron emission tomography (PET) with radiotracers targeting these age-related changes has been increasingly employed to clarify the sequence of their occurrence and the evolution of clinically cognitive deficits. Herein, we reviewed recent literature on PET-based imaging of normal human brain aging in terms of neural activity, Aβ, and tau. Neural hypoactivity reflected by decreased glucose utilization with PET imaging has been predominately reported in the frontal, cingulate, and temporal lobes of the normal aging brain. Aβ PET imaging uncovers the pathophysiological association of Aβ deposition with cognitive aging, as well as the potential mechanisms. Tau-associated cognitive changes in normal aging are likely independent of but facilitated by Aβ as indicated by tau and Aβ PET imaging. Future longitudinal studies using multi-radiotracer PET imaging combined with other neuroimaging modalities, such as magnetic resonance imaging (MRI) morphometry, functional MRI, and magnetoencephalography, are essential to elucidate the neuropathological underpinnings and interactions in normal brain aging. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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