The impact of removing former drinkers from genome‐wide association studies of AUDIT‐C.
Background and aims: The Alcohol Use Disorders Identification Test‐Consumption (AUDIT‐C) questionnaire screens for harmful drinking using a 12‐month timeframe. A score of 0 is assigned to individuals who report abstaining from alcohol in the past year. However, many middle‐age individuals reporting...
| Publicado en: | Addiction Vol. 116; no. 11; pp. 3044 - 3055 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Nov2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152818827&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152818827 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Nov2021 vid: 116 iid: 11 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 152818827 150162482 152818827 152818827 10.1111/add.15511 152818827 ppf: 3044 ppct: 11 formats: fmt: @attributes: type: P tig: atl: The impact of removing former drinkers from genome‐wide association studies of AUDIT‐C. aug: au: Dao, Cecilia Zhou, Hang Small, Aeron Gordon, Kirsha S. Li, Boyang Kember, Rachel L. Ye, Yixuan Gelernter, Joel Xu, Ke Kranzler, Henry R. Zhao, Hongyu Justice, Amy C. affil: Yale University School of Public Health, New Haven CT,, USA sug: subj: Research Subject Recruitment Genome Wide Association Study Alcohol Drinking Clinical Assessment Tools Health Screening Alcoholism Risk Factors Risk Assessment Alcohol Abstinence Human Questionnaires United Kingdom Polymorphism, Single Nucleotide Alleles Depression ab: Background and aims: The Alcohol Use Disorders Identification Test‐Consumption (AUDIT‐C) questionnaire screens for harmful drinking using a 12‐month timeframe. A score of 0 is assigned to individuals who report abstaining from alcohol in the past year. However, many middle‐age individuals reporting current abstinence are former drinkers (FDs). Because FDs may be more genetically prone to harmful alcohol use than lifelong abstainers (LAs) and are often combined with LAs, we evaluated the impact of differentiating them on the identification of genetic association. Design and Setting: The United Kingdom Biobank (UKBB) includes AUDIT‐C and alcohol drinker status. Participants: 131 510 Europeans, including 5135 FDs. Measurements We compared three genome‐wide association (GWAS) analyses to explore the effects of removing FDs: the full AUDIT‐C data, AUDIT‐C data without FDs, and data from a random sample numerically matched to the data without FDs. Because prior studies show a consistent association of the ADH1B polymorphism rs1229984 with both alcohol consumption and alcohol use disorder, we compared allele frequencies for rs1229984 stratified by AUDIT‐C value and FD versus LA status. Additionally, we calculated polygenic risk scores (PRS) of related diseases. Findings The rs1229984 allele frequencies among FDs were numerically comparable to those with high AUDIT‐C scores and very different from those of LAs. Removing FDs from GWAS yielded a stronger association with rs1229984 (P value after removal: 1.9 × 10−70 vs 1.7 × 10−65 and 2.5 × 10−62), more statistically significant single nucleotide polymorphisms (SNPs) (after removal: 11 vs 9 and 8), and genomic loci (after removal: 11 vs 9 and 7). Additional independent SNPs were identified after removal of FDs: rs2817866 (PTGER3), rs7105867 (ANO3), and rs17601612 (DRD2). For PRS of alcohol use disorder and major depressive disorder, there are statistically significant differences between FDs and LAs. Conclusions: Differentiating between former drinkers and lifelong abstainers can improve Alcohol Use Disorders Identification Test‐Consumption (AUDIT‐C) genome‐wide association results. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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