Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia with e1a3 BCR-ABL1 transcript in a Nigerian with sickle cell anemia: a case report.
Background: The occurrence of acute leukemia in patients with sickle cell anemia is uncommon. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia. However, it may also be associated with acute lymphoblastic leukemia and acute myeloblastic leukemia. The common BCR-ABL1 transcripts...
| Published in: | Journal of Medical Case Reports Vol. 15; no. 1; pp. 1 - 9 |
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| Main Authors: | , , , , |
| Format: | case study Journal Article |
| Published: |
BioMed Central
10/8/2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=152896983&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 152896983 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17521947 8X8Q jtl: Journal of Medical Case Reports issn: 17521947 maglogo: N pubinfo: dt: 10/8/2021 vid: 15 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 152896983 152896983 NLM34625105 152896983 10.1186/s13256-021-03060-5 NLM34625105 152896983 ppf: 1 ppct: 8 formats: tig: atl: Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia with e1a3 BCR-ABL1 transcript in a Nigerian with sickle cell anemia: a case report. aug: au: Ahmed, Ibrahim O. Ochogwu, Lauretta O. Owojuyigbe, Temilola O. Akinola, Norah O. Durosinmi, Muheez A. affil: Department of Haematology and Blood Transfusion, Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria sug: subj: Anemia, Sickle Cell Complications Anemia, Sickle Cell Leukemia, Lymphocytic, Acute Young Adult Nigeria Proteins Adult Chromosome Disorders Male B Lymphocytes Scales Adult: 19-44 years Male ab: Background: The occurrence of acute leukemia in patients with sickle cell anemia is uncommon. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia. However, it may also be associated with acute lymphoblastic leukemia and acute myeloblastic leukemia. The common BCR-ABL1 transcripts seen in acute lymphoblastic leukemia are e1a2, e13a2, and e14a2, while other transcripts such as e1a3, e13a3, and e6a2 occur rarely. This report describes the presentation, management, and outcome of the occurrence of B-cell acute lymphoblastic leukemia with the rare e1a3 BCR-ABL1 transcript in a patient with sickle cell anemia.Case Presentation: A 19-year-old male Nigerian, a known sickle cell anemia patient was admitted on account of severe vaso-occlusive crisis. Examination revealed fever, palor, and jaundice. Full blood count showed anemia and leukocytosis. Peripheral blood and bone marrow smears revealed numerous large and small lymphoblasts in keeping with the L2 subtype of acute lymphoblastic leukemia based on the French-American-British classification. Further evaluation was in keeping with a diagnosis of BCR-ABL1-positive mature B-cell acute lymphoblastic leukemia associated with the rare e1a3 transcript. He was commenced simultaneously on induction chemotherapy and Imatinib while being prepared for allogeneic stem cell transplantation. However, he died six months after diagnosis from meningoencephalitis.Conclusion: The occurrence of acute lymphoblastic leukemia with a rare BCR-ABL1 e1a3 transcript in association with sickle cell anemia is uncommon and associated with poor prognosis. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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