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Maturational changes in sodium metabolism in periviable infants.

Background: Sodium depletion results in impaired somatic growth. The sodium requirements of extremely preterm (periviable) infants early in life are not known. We therefore investigated sodium homeostasis in this population over the first 10 weeks following birth. Methods: This was a longitudinal, o...

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Published in:Pediatric Nephrology Vol. 36; no. 11; pp. 3693 - 3699
Main Authors: Segar, Jeffrey L, Grobe, Connie C, Grobe, Justin L
Format: research tables/charts Journal Article
Published: Springer Nature Nov2021
Online Access:View this record in EBSCOhost
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      dt: Nov2021
      vid: 36
      iid: 11
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00467-021-05119-3
        152899944
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        atl: Maturational changes in sodium metabolism in periviable infants.
      aug:
        au:
          Segar, Jeffrey L
          Grobe, Connie C
          Grobe, Justin L
        affil: Division of Neonatology, Department of Pediatrics, Medical College of Wisconsin, 999 North 92nd St, Suite C410, 53226, Milwaukee, WI, USA
      sug:
        subj:
          Infant, Premature
          Sodium, Dietary Metabolism
          Homeostasis Evaluation
          Outcomes of Prematurity
          Growth
          Human
          Prospective Studies
          Nonexperimental Studies
          Infant, Newborn
          Infant
          Sodium, Dietary Urine
          Convenience Sample
          Food Intake
          Descriptive Statistics
          Fluid Intake-Output Measures
          Fluid-Electrolyte Balance
          Hyponatremia
          Weight Gain
          Infant, Newborn: birth-1 month
          Infant: 1-23 months
      ab: Background: Sodium depletion results in impaired somatic growth. The sodium requirements of extremely preterm (periviable) infants early in life are not known. We therefore investigated sodium homeostasis in this population over the first 10 weeks following birth. Methods: This was a longitudinal, observational study of sodium intake and urine sodium excretion in a convenience cohort of 23 infants born at 22 0/7–23 6/7-week gestation. Results: Sodium intake ranged from 5.2 ± 0.4 to a maximum of 7.9 ± 0.5 mEq/kg/day at 2 and 8 weeks of postnatal age, respectively, while urinary sodium loss was 7.7 ± 1.0 mEq/kg/day and 6.9 ± 0.7 mEq/kg/day at these time points. Sodium balance (sodium intake – urine sodium output) was first positive at 6 weeks of age, though a positive sodium balance exceeding 1.4 mEq/kg/day (i.e., a balance associated with weight gain of 30 g/day) was not observed until 10 weeks. Conclusions: Infants born at 22–23-week gestational age have a prolonged period of high urinary losses of sodium and negative sodium balance. Sodium intakes greater than those currently recommended by the American Academy of Pediatrics are needed to achieve a significant positive sodium balance in this population.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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