Lateral ankle instability-induced neuroplasticity in brain grey matter: A voxel-based morphometry MRI study.
Objectives: The deficits in sensory pathways caused by peripheral edema, pain, and inflammation of the damaged ligaments may induce maladaptive changes within the central nervous system. The purpose of this study was to determine whether patients with lateral ankle instability (LAI) exhibit morpholo...
| Publicado en: | Journal of Science & Medicine in Sport Vol. 24; no. 12; pp. 1240 - 1245 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Dec2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153095751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153095751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14402440 1FKA jtl: Journal of Science & Medicine in Sport issn: 14402440 maglogo: N pubinfo: dt: Dec2021 vid: 24 iid: 12 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 153095751 153095751 NLM34281769 10.1016/j.jsams.2021.06.013 NLM34281769 153095751 ppf: 1240 ppct: 5 formats: tig: atl: Lateral ankle instability-induced neuroplasticity in brain grey matter: A voxel-based morphometry MRI study. aug: au: Xue, Xiao'ao Zhang, Yuyang Li, Shengkun Xu, Hanlin Chen, Shuang Hua, Yinghui affil: Department of Sports Medicine, Huashan Hospital, Fudan University, China sug: subj: Gray Matter Joint Instability Physiopathology Neuronal Plasticity Physiology Magnetic Resonance Imaging Gray Matter Physiopathology Ankle Joint Physiopathology Body Weights and Measures Male Female Cross Sectional Studies Young Adult Adult Questionnaires Adult: 19-44 years Male Female ab: Objectives: The deficits in sensory pathways caused by peripheral edema, pain, and inflammation of the damaged ligaments may induce maladaptive changes within the central nervous system. The purpose of this study was to determine whether patients with lateral ankle instability (LAI) exhibit morphological differences of brain grey matter when compared with healthy controls, and then assess the relationships between the observed differences and the characteristics of patients.Design: Cross-sectional.Methods: Thirty patients with LAI and 32 healthy controls without LAI underwent MRI scans using anatomical T1 sequences. A voxel-wise general linear model was used to compare the grey matter volume throughout the whole brain between patients and controls. Linear regression analyses were performed for the grey matter volume within the significant clusters to assess their relationship with age, sex, the existence of acute injury, pain level, sports activity level, and the duration of LAI within the patient group.Results: The grey matter volume of a cluster within the cerebellar vermis (Vermis_4_5 in automated anatomical labeling template) was significantly reduced in patients with LAI (Gaussian Random Field corrections with two-tailed p-cluster < 0.05 and p-voxel < 0.001). Multivariate linear regression analysis revealed that the duration of LAI tended to be passively associated with the grey matter volume of this LAI-related vermal cluster (p = 0.092).Conclusions: Participants with LAI exhibited a reduced grey matter volume of a cluster within the cerebellar vermis compared with participants without LAI, and the degree of volume reduction tended to be positively associated with the duration of LAI. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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