The role of 2-hydroxyglutarate magnetic resonance spectroscopy for the determination of isocitrate dehydrogenase status in lower grade gliomas versus glioblastoma: a systematic review and meta-analysis of diagnostic test accuracy.
Purpose: Magnetic resonance spectroscopy (MRS) provides a non-invasive means of determining isocitrate dehydrogenase (IDH) status. Determination of 2-hydroxyglutarate (2-HG) presence through MRS is a means of determining IDH status; however, differences may be seen by grade. The goal of this paper i...
| Publicado en: | Neuroradiology Vol. 63; no. 11; pp. 1823 - 1831 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153124013&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153124013 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Nov2021 vid: 63 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 153124013 149610404 153124013 153124013 10.1007/s00234-021-02702-1 153124013 ppf: 1823 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The role of 2-hydroxyglutarate magnetic resonance spectroscopy for the determination of isocitrate dehydrogenase status in lower grade gliomas versus glioblastoma: a systematic review and meta-analysis of diagnostic test accuracy. aug: au: Bhandari, Abhishta Sharma, Chinmay Ibrahim, Muhammad Riggs, Matthew Jones, Rhondda Lasocki, Arian affil: Townsville University Hospital, 100 Angus Smith Drive, 4814, Douglas, Queensland, Australia sug: subj: Glioma Diagnosis Neoplasm Grading Oxidoreductases Blood Magnetic Resonance Spectroscopy Methods Glioma Surgery Preoperative Care Cancer Patients Human Systematic Review Meta Analysis Predictive Value of Tests Preoperative Period Oxidoreductases Metabolism Checklists Descriptive Statistics Sensitivity and Specificity PubMed ab: Purpose: Magnetic resonance spectroscopy (MRS) provides a non-invasive means of determining isocitrate dehydrogenase (IDH) status. Determination of 2-hydroxyglutarate (2-HG) presence through MRS is a means of determining IDH status; however, differences may be seen by grade. The goal of this paper is to perform a diagnostic test accuracy (DTA) meta-analysis on 2-HG MRS for IDH status in both lower-grade glioma (LGG) and glioblastoma (GBM) in preoperative patients. Methods: A systematic review and meta-analysis were performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Diagnostic Test Accuracy guidelines. Quality assessment was performed using the Quality Assessment of Diagnostic Accuracy Studies 2. The search was up to date as of 09/02/2021. Nine English-language journal articles were included. Results: The meta-analysis found a pooled sensitivity of 93% (95% CI 58–99%) and specificity of 84% (95% CI 51–96%) for LGG (n= 181). For GBM (n= 77), the pooled sensitivity was 84% (95% CI 25.0–99%) and the specificity was 97% (95% CI 43–100%). Conclusion: 2-HG MRS shows promise as a non-invasive means of determining IDH status, with specificity higher for GBM and sensitivity higher for LGG. The wide confidence intervals are notable, however, in particular related to the small number of IDH-mutant GBM studied. Diagnostic heterogeneity was particularly present for LGG, and the hierarchical summary receiver operator curves showed poor predictive accuracy in both groups. For more conclusive results, diagnostic test accuracy statistics need to be quantified with larger studies and more deliberate study design. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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