PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.
Background. PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear. Methods. PLOD2 expression and CESC patients' survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier...
| Publicado en: | BioMed Research International pp. 1 - 12 |
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| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
10/23/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153185887&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153185887 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 10/23/2021 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 153185887 153185887 153185887 10.1155/2021/5512340 153185887 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer. aug: au: Li, Guang Wang, Xuefeng Liu, Guobing affil: Department of Obstetrics and Gynecology, Third Affiliated Hospital of Southern Medical University, Guangzhou, 510515 Guangdong Province, China sug: subj: Cervix Neoplasms Prognosis Tumor Markers, Biological Gene Expression Signal Transduction Cell Line, Tumor Cervix Neoplasms Immunology Oxidoreductases Human Survival Analysis Kaplan-Meier Estimator Immunohistochemistry Cell Physiology Cell Proliferation B Lymphocytes T Lymphocytes ab: Background. PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear. Methods. PLOD2 expression and CESC patients' survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate the expression of PLOD2 in CESC; Gene Set Enrichment Analysis was performed using the STRING and DAVID databases; and the correlations between PLOD2 and cancer immune infiltrates were investigated using the TIMER and TISIDB databases. Results. We found that the expression level of PLOD2 was increased in various cancers, and meta-analysis in the Oncomine database revealed that PLOD2 was significantly upregulated in CESC compared to that in normal tissues (P < 0.001). In addition, the high expression of PLOD2 was closely related to poor overall survival (OS) and disease-free survival (DFS) in patients with CESC (OS HR = 1.73 , P = 0.029 ; DFS HR = 2.60 , P = 0.018). Functional annotations indicated that differentially expressed PLOD2 were primarily related to protein digestion and absorption pathways and to the collagen fibril organization process. Immune infiltration analysis showed that PLOD2 was highly correlated with B cells, CD4+ T cells, T helper type 2 (Th2) cells, and eosinophils in CESC. Conclusion. PLOD2 is positively associated with poor prognosis and might be considered a novel diagnostic and prognostic marker for CESC patients. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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