Benchmarking Various Radiomic Toolkit Features While Applying the Image Biomarker Standardization Initiative toward Clinical Translation of Radiomic Analysis.

The image biomarkers standardization initiative (IBSI) was formed to address the standardization of extraction of quantifiable imaging metrics. Despite its effort, there remains a lack of consensus or established guidelines regarding radiomic feature terminology, the underlying mathematics and their...

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Publicado en:Journal of Digital Imaging Vol. 34; no. 5; pp. 1156 - 1171
Autores principales: Lei, Mingxi, Varghese, Bino, Hwang, Darryl, Cen, Steven, Lei, Xiaomeng, Desai, Bhushan, Azadikhah, Afshin, Oberai, Assad, Duddalwar, Vinay
Formato: equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Oct2021
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Oct2021
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      pub: Springer Nature
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        10.1007/s10278-021-00506-6
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        atl: Benchmarking Various Radiomic Toolkit Features While Applying the Image Biomarker Standardization Initiative toward Clinical Translation of Radiomic Analysis.
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          Lei, Mingxi
          Varghese, Bino
          Hwang, Darryl
          Cen, Steven
          Lei, Xiaomeng
          Desai, Bhushan
          Azadikhah, Afshin
          Oberai, Assad
          Duddalwar, Vinay
        affil: Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, 3740 McClintock Avenue, 90089, Los Angeles, CA, USA
      sug:
        subj:
          Radiography
          Benchmarking
          Biological Markers Standards
          Software
          Digital Imaging
          Human
          Interrater Reliability
          Radiographic Image Enhancement
          Workflow
          Computers and Computerization
      ab: The image biomarkers standardization initiative (IBSI) was formed to address the standardization of extraction of quantifiable imaging metrics. Despite its effort, there remains a lack of consensus or established guidelines regarding radiomic feature terminology, the underlying mathematics and their implementation across various software programs. This creates a scenario where features extracted using different toolboxes cannot be used to build or validate the same model leading to a non-generalization of radiomic results. In this study, IBSI-established phantom and benchmark values were used to compare the variation of the radiomic features while using 6 publicly available software programs and 1 in-house radiomics pipeline. All IBSI-standardized features (11 classes, 173 in total) were extracted. The relative differences between the extracted feature values from the different software programs and the IBSI benchmark values were calculated to measure the inter-software agreement. To better understand the variations, features are further grouped into 3 categories according to their properties: 1) morphology, 2) statistic/histogram and 3)texture features. While a good agreement was observed for a majority of radiomics features across the various tested programs, relatively poor agreement was observed for morphology features. Significant differences were also found in programs that use different gray-level discretization approaches. Since these software programs do not include all IBSI features, the level of quantitative assessment for each category was analyzed using Venn and UpSet diagrams and quantified using two ad hoc metrics. Morphology features earned lowest scores for both metrics, indicating that morphological features are not consistently evaluated among software programs. We conclude that radiomic features calculated using different software programs may not be interchangeable. Further studies are needed to standardize the workflow of radiomic feature extraction.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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