Replicability in measures of attentional set-shifting task performance predicting chronic heavy drinking in rhesus monkeys.
This study was designed to replicate and extend a previous report that the increase in performance of an attentional set-shifting task (ASST) in rhesus monkeys predicted their future alcohol drinking status as a heavy drinker (HD) or non-heavy drinker (NHD). A cohort of 6 young adult male monkeys wa...
| Publicado en: | Alcohol Vol. 96; pp. 93 - 99 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Nov2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153292127&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153292127 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07418329 J8J jtl: Alcohol issn: 07418329 maglogo: N pubinfo: dt: Nov2021 vid: 96 pid: 82545 pub: Elsevier B.V. place: Philadelphia, Pennsylvania artinfo: ui: 153292127 153292127 NLM34509594 153292127 10.1016/j.alcohol.2021.08.006 NLM34509594 153292127 ppf: 93 ppct: 6 formats: tig: atl: Replicability in measures of attentional set-shifting task performance predicting chronic heavy drinking in rhesus monkeys. aug: au: Grant, K.A. Newman, N. Gonzales, S. Shnitko, T.A. affil: Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, 97006, United States sug: subj: Task Performance and Analysis Alcoholic Intoxication Primates Alcohol Drinking Male Ethanol Animal Studies Funding Source Male ab: This study was designed to replicate and extend a previous report that the increase in performance of an attentional set-shifting task (ASST) in rhesus monkeys predicted their future alcohol drinking status as a heavy drinker (HD) or non-heavy drinker (NHD). A cohort of 6 young adult male monkeys was trained and tested under the same ASST and then underwent a alcohol self-administration protocol that maintained open-access (22 hours/day) choice of alcohol or water 7 days/week for approximately 6 months. The average improvement in performance in the ASST, as measured by a performance index, was replicated in the cohort of 6 monkeys when compared to the increase in the task performance in a previous cohort of 9 male monkeys. The alcohol self-administration protocol was then used to determine the drinking status (HD: n = 4 or NHD: n = 2) of the replicate cohort, which was accurately predicted by the performance on the ASST. Finally, individuals from both cohorts could be combined based on future drinking status of HD (n = 8) or NHD (n = 7), and the association with pre-alcohol ASST performance remained. Specifically, monkeys that had lower rates of PI improvement were more likely to become HDs. To our knowledge, this is the first study to replicate that deficits in the set-shifting performance can predict chronic heavy alcohol drinking in primates. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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