Is there a dysbiosis in individuals with a neurodevelopmental disorder compared to controls over the course of development? A systematic review.
Many scientific papers reported that an unbalanced gut microbiota could lead to or worsen neurodevelopmental disorders (NDD). A dysbiosis may then be observed in the course of development and mark a dysfunction within what is called the gut-brain axis. The aim of this systematic review is to investi...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 30; no. 11; pp. 1671 - 1695 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153317661&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153317661 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Nov2021 vid: 30 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 153317661 144040285 153317661 153317661 10.1007/s00787-020-01544-1 153317661 ppf: 1671 ppct: 24 formats: fmt: @attributes: type: P tig: atl: Is there a dysbiosis in individuals with a neurodevelopmental disorder compared to controls over the course of development? A systematic review. aug: au: Jurek, Lucie Sevil, Marine Jay, Agathe Schröder, Carmen Baghdadli, Amaria Héry-Arnaud, Geneviève Geoffray, Marie-Maude affil: Child and Adolescent Psychiatry Departement, Center for Assessment and Diagnostic of Autism, Le Vinatier Hospital, Bron, France sug: subj: Mental Disorders Diagnosed in Childhood Mental Disorders In Adulthood Gut Microbiota In Infancy and Childhood Pathologic Processes In Infancy and Childhood Gut Microbiota In Adulthood Pathologic Processes In Adulthood Human Systematic Review Developmental Disabilities Brain Physiology Medline Psycinfo Attention Deficit Hyperactivity Disorder Autism Spectrum Disorder Child Young Adult Child: 6-12 years ab: Many scientific papers reported that an unbalanced gut microbiota could lead to or worsen neurodevelopmental disorders (NDD). A dysbiosis may then be observed in the course of development and mark a dysfunction within what is called the gut-brain axis. The aim of this systematic review is to investigate potential evidence of dysbiosis in children and young adults with NDD compared to controls. Using the PRISMA guidelines we systematically reviewed studies that compared the gut microbiota in NDD participants (with an age inferior to thirty) to the gut microbiota of controls, regardless of the data analysis methods used. The MEDLINE, Scopus and PsycINFO databases were searched up to September 2018. 31 studies with a total sample size of 3002 ASD (Autism Spectrum Disorder) and 84 ADHD (Attention Deficit Hyperactivity Disorder) participants were included in this systematic review. Independent data extraction and quality assessment were conducted. The quality of the studies was rated from low to high. Population characterization and experimental methods were highly heterogeneous in terms of the data available, selection of criteria, and dysbiosis measurement. A dysbiosis was reported in 28 studies in terms of either diversity, bacterial composition or metabolome dysfunction. Due to heterogeneity, a quantitative synthesis was not applicable. In this paper, we discuss the different biases to understand the complexity of microbiota and neurodevelopmental disorders to provide leads for future cohort studies looking to answer the questions raised by the trillions of microorganisms that inhabit key body niches. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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