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Disrupted communication of the temporoparietal junction in patients with major depressive disorder.

Patients with major depressive disorder (MDD) suffer impairment in the transmission and integration of internal and external information sources. Accumulating evidence suggests that the temporoparietal junction (TPJ) is important for multiple cognitive and social functions and may act as a key node...

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Published in:Cognitive, Affective & Behavioral Neuroscience Vol. 21; no. 6; pp. 1276 - 1297
Main Authors: Wen, Xiaotong, Liu, Yuan, Zhao, Ping, Liu, Zhenghao, Li, Huanhuan, Li, Wen, Zhu, Zhiyuan, Wu, Xia
Format: Journal Article
Published: Springer Nature Dec2021
Online Access:View this record in EBSCOhost
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      dt: Dec2021
      vid: 21
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      pub: Springer Nature
      place: New York, New York
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        150739290
        10.3758/s13415-021-00918-5
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        atl: Disrupted communication of the temporoparietal junction in patients with major depressive disorder.
      aug:
        au:
          Wen, Xiaotong
          Liu, Yuan
          Zhao, Ping
          Liu, Zhenghao
          Li, Huanhuan
          Li, Wen
          Zhu, Zhiyuan
          Wu, Xia
        affil: Department of Psychology, Renmin University of China, 100872, Beijing, China
      sug:
      ab: Patients with major depressive disorder (MDD) suffer impairment in the transmission and integration of internal and external information sources. Accumulating evidence suggests that the temporoparietal junction (TPJ) is important for multiple cognitive and social functions and may act as a key node for the integration of internal and external information. Therefore, the TPJ's aberrant interaction mechanism may underpin MDD psychopathology. To answer this question, we conducted a comprehensive study using resting-state functional magnetic imaging data recorded from 74 patients with MDD and 69 normal controls. First, we examined whether TPJ was the most prominent region with altered functional/effective connectivity with multiple depression-related regions/networks, based on either zero-lag correlations or temporal mutual information (total interdependence and Granger causality) measurements. Accordingly, we derived a network model that depicts alterations of TPJ-connectivity in patients with MDD. Lastly, we performed a cross-approach comparison demonstrating more conducive indicators in delineating the network alteration model. Functional/effective connectivity between the TPJ and major functional networks that govern internal and external-driven information resources was attenuated in patients with MDD. TPJ acts like a key node for information-inflow and integration of multiple information streams. Therefore, dysfunctional connectivity indicators may serve as effective biomarkers for MDD. MDD is associated with the breakdown of the TPJ interaction model and its connections with the default mode network and the task-positive network.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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