Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients.

Oral carcinoma represents one of the most common malignancies worldwide. Oral squamous cell carcinomas (OSCCs) account over 90% of all oral malignant tumors and are characterized by high mortality in the advanced stages. Early diagnosis is often a challenge for its ambiguous appearance in early stag...

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Publicado en:BioMed Research International pp. 1 - 12
Autores principales: Muzio, Lorenzo Lo, Ballini, Andrea, Cantore, Stefania, Bottalico, Lucrezia, Charitos, Ioannis Alexandros, Ambrosino, Mariateresa, Nocini, Riccardo, Malcangi, Annarita, Dioguardi, Mario, Cazzolla, Angela Pia, Brauner, Edoardo, Santacroce, Luigi, Cosola, Michele Di
Formato: pictorial review tables/charts Journal Article
Publicado: Wiley-Blackwell 11/2/2021
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 11/2/2021
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1155/2021/7312611
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        atl: Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients.
      aug:
        au:
          Muzio, Lorenzo Lo
          Ballini, Andrea
          Cantore, Stefania
          Bottalico, Lucrezia
          Charitos, Ioannis Alexandros
          Ambrosino, Mariateresa
          Nocini, Riccardo
          Malcangi, Annarita
          Dioguardi, Mario
          Cazzolla, Angela Pia
          Brauner, Edoardo
          Santacroce, Luigi
          Cosola, Michele Di
        affil: Department of Clinical and Experimental Medicine, Università Degli Studi di Foggia, Foggia 71122, Italy
      sug:
        subj:
          Candidiasis, Oral
          Papillomavirus Infections
          Biochemical Phenomena
          Mouth Neoplasms Epidemiology
          Mouth Neoplasms Physiopathology
          Mouth Neoplasms Risk Factors
          Pediatric Dentistry
          Squamous Cell Carcinoma of Head and Neck
          Early Detection of Cancer
          Microbiota
      ab: Oral carcinoma represents one of the most common malignancies worldwide. Oral squamous cell carcinomas (OSCCs) account over 90% of all oral malignant tumors and are characterized by high mortality in the advanced stages. Early diagnosis is often a challenge for its ambiguous appearance in early stages. Mucosal infection by the human papillomavirus (HPV) is responsible for a growing number of malignancies, particularly cervical cancer and oropharyngeal carcinomas. In addition, Candida albicans (C. albicans), which is the principal fungi involved in the oral cancer development, may induce carcinogenesis through several mechanisms, mainly promoting inflammation. Medical knowledge and research on adolescent/pediatric patients' management and prevention are in continuous evolution. Besides, microbiota can play an important role in maintaining oral health and therefore all human health. The aim of this review is to evaluate epidemiological and pathophysiological characteristics of the several biochemical pathways involved during HPV and C. albicans infections in pediatric dentistry.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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