Enhancing the Sensitivity of Memory Tests: Reference Data for the Free and Cued Selective Reminding Test and the Logical Memory Task from Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels.
Background: Cognitive performance of a given individual should be interpreted in the context of reference standards obtained in cognitively healthy populations. Recent evidence has shown that removing asymptomatic individuals with biomarker evidence of Alzheimer's disease pathology from normative sa...
| Publicado en: | Journal of Alzheimer's Disease Vol. 84; no. 1; pp. 119 - 129 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Sage Publications Inc.
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153410567&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153410567 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872877 FLR jtl: Journal of Alzheimer's Disease issn: 13872877 maglogo: N pubinfo: dt: 2021 vid: 84 iid: 1 pid: 20732 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 153410567 153410567 NLM34569957 153410567 10.3233/JAD-210640 NLM34569957 153410567 ppf: 119 ppct: 10 formats: tig: atl: Enhancing the Sensitivity of Memory Tests: Reference Data for the Free and Cued Selective Reminding Test and the Logical Memory Task from Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels. aug: au: Brugulat-Serrat, Anna Cañas-Martínez, Alba Canals-Gispert, Lidia Marne, Paula Gramunt, Nina Milà-Alomà, Marta Suárez-Calvet, Marc Arenaza-Urquijo, Eider M. Grau-Rivera, Oriol González-de-Echávarri, José María Minguillon, Carolina Fauria, Karine Kollmorgen, Gwendlyn Suridjan, Ivonne Zetterberg, Henrik Blennow, Kaj Gispert, Juan Domingo Molinuevo, José Luis Sánchez-Benavides, Gonzalo affil: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain sug: subj: Neuropsychological Tests Standards Neuropsychological Tests Statistics and Numerical Data Alzheimer's Disease Cerebrospinal Fluid Research Subjects Statistics and Numerical Data Memory Disorders Diagnosis Female Human Male Nerve Tissue Proteins Cerebrospinal Fluid Peptides Cerebrospinal Fluid Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales Female Male ab: Background: Cognitive performance of a given individual should be interpreted in the context of reference standards obtained in cognitively healthy populations. Recent evidence has shown that removing asymptomatic individuals with biomarker evidence of Alzheimer's disease pathology from normative samples increases the sensitivity of norms to detect memory impairments. These kind of norms may be useful for defining subtle cognitive decline, the transitional cognitive decline between normal cognition and mild cognitive impairment.Objective: The present study aims to provide norms for the Free and Cued Selective Reminding Test (FCSRT) and the Logical Memory subtest of the Wechsler Memory Scale-IV in a sample of individuals aged 50-70 years with normal levels of amyloid-β and tau cerebrospinal fluid (CSF) biomarkers.Methods: The sample was composed of 248 individuals from the ALFA+ study with negative amyloid-β and tau CSF biomarker levels. Regression-based norms were developed, including adjustments for age, education, and sex when applicable.Results: We found that education was associated with the performance in all the variables of both tests while age had a marginal effect only in the delayed free recall of the FCSRT. Sex was also related to the performance in the FCSRT, with women outperforming men. Equations to calculate z-scores and normative percentile tables were created. As compared with previously published norms the reference data presented were more sensitive but less specific, as expected.Conclusion: The use of the norms provided in this work, in combination with the already published conventional norms, may contribute to detecting subtle memory impairment. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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