High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer.
This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association b...
| Publicado en: | BioMed Research International pp. 1 - 11 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
11/5/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153417388&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153417388 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 11/5/2021 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 153417388 153417388 153417388 10.1155/2021/5282894 153417388 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer. aug: au: Cui, Yun-Qian Meng, Fei Zhan, Wen-Li Dai, Zhou-Tong Liao, Xinghua affil: School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China sug: subj: Proteins Gene Expression Kidney Neoplasms Prognosis Carcinoma, Renal Cell Prognosis Risk Assessment Tumor Markers, Biological Human In Vitro Studies Cell Line, Tumor Cell Proliferation ab: This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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