Mortality in substance‐induced psychosis: a register‐based national cohort study.
Aims: We aimed to analyze whether people with substance‐induced psychosis (SIP), both those who convert and do not convert to schizophrenia, have higher all‐cause and cause‐specific mortality when compared to the general population. Design Prospective cohort study. Setting: Nationwide Danish registe...
| Publicado en: | Addiction Vol. 116; no. 12; pp. 3515 - 3525 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153434453&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153434453 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Dec2021 vid: 116 iid: 12 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 153434453 151039660 153434453 153434453 10.1111/add.15598 153434453 ppf: 3515 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Mortality in substance‐induced psychosis: a register‐based national cohort study. aug: au: Hjorthøj, Carsten Madsen, Trine Starzer, Marie Erlangsen, Annette Nordentoft, Merete affil: Copenhagen Research Center for Mental Health – CORE, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark sug: subj: Psychoses, Substance-Induced Mortality Schizophrenia Substance Use Disorders Complications Cause of Death Human Prospective Studies Denmark Adolescence Adult Middle Age Aged Confidence Intervals Descriptive Statistics Suicide Death, Accidental Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: Aims: We aimed to analyze whether people with substance‐induced psychosis (SIP), both those who convert and do not convert to schizophrenia, have higher all‐cause and cause‐specific mortality when compared to the general population. Design Prospective cohort study. Setting: Nationwide Danish registers. Participants/Cases: We included all people born in Denmark, living in Denmark on their 15th birthday, and age 15 or more during the study period from January 1, 1994, and August 10, 2017. Measurements Exposure was categorized as: (i) neither SIP nor schizophrenia; (ii) SIP without preceding schizophrenia; (iii) SIP converted to schizophrenia; and (iv) schizophrenia without preceding SIP. Any SIP and substance‐specific SIPS were examined regarding all‐cause and cause‐specific mortality. Findings The study included a total of 5 619 691 individuals. Compared to people with neither schizophrenia nor SIP, people with SIP without preceding schizophrenia had an increased risk of dying (hazard ratio [HR] = 6.23, 95% CI = 5.96–6.50), as had those with SIP converting to schizophrenia (HR = 9.77, 95% CI = 8.84–10.79) and those with only schizophrenia (HR = 3.07, 95% CI = 3.03–3.13). A similar pattern, albeit with higher HRs, was observed for suicides and accidental deaths. Other cause‐specific‐mortality groups also generally showed the same pattern, as did types of individual substances. Conclusions: Substance‐induced psychosis was strongly associated with an increased risk of both all‐cause and cause‐specific mortality, even among cases who did not convert to schizophrenia. This provides a strong rationale for monitoring people with previous diagnosis of substance‐induced psychosis and developing and implementing interventions to reduce this excess mortality. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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